自噬在脊髓细胞中的作用与机制研究进展  

Role and Mechanism of Autophagy in Spinal Cord Cells

作　　者：朱宁 杨新明[2] 张瑛[2] ZHU Ning;YANG Xin-ming;ZHANG Ying(Graduate School of Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Orthopaedics,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)

机构地区：[1]河北北方学院研究生院,河北张家口075000 [2]河北北方学院附属第一医院骨科,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2020年第6期51-55,共5页Journal of Hebei North University:Natural Science Edition

基　　金：河北省卫生厅2011年医学科学研究重点项目计划(No.20110176);2013年度河北北方学院创新人才培育基金项目(No.CXRC1322)。

摘　　要：脊髓损伤(spinal cord injury,SCI)是脊柱外科常见的复杂神经系统疾病,尽管不同脊髓损伤存在病理生理差异,但在许多方面损伤机制相似。损伤引起的一系列生化变化为继发性损伤,存在自噬迹象,但自噬的机制仍不清楚。综述了脊髓损伤后自噬在不同类型细胞中作用机制的研究进展及自噬对受损组织的影响。Spinal cord injury(SCI),a complex diseases of the nervous system,is common in spinal surgery.Although there are important pathophysiological differences between different spinal cord injuries,mechanisms are similar in many ways.A series of biochemical changes caused by damage are secondary damage,and signs of autophagy have been observed,but its mechanism and consequences remain unclear.This paper reviews the latest advances in autophagy in different cell types following spinal cord injury and the effects of autophagy on damaged tissues.

关 键 词：脊髓损伤 自噬 神经元 神经胶质细胞 

分 类 号：R651.2[医药卫生—外科学]