PET-MRI脑部定量准确性对比研究:MRI与PET脑分区对SUVR计算的影响  

A comparative study of PET-MRI brain quantitative accuracy: the effect of MRI based segmentation and PET based segmentation on SUVR calculation

作　　者：李再升 宋双双 曾天翼 卢洁[5,6,7] 胡凌志 陈群 LI Zaisheng;SONG Shuangshuang;ZENG Tianyi;LU Jie;HU Lingzhi;CHEN Qun(Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai 201210,China;School of Information Science and Technology,ShanghaiTech University,Shanghai 201210,China;University of Chinese Academy of Sciences,Beijing 100049,China;Shanghai United Imaging Healthcare Co.,Ltd.,Shanghai 201807,China;Department of Radiology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics,Beijing 100053,China;Department of Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]中国科学院上海高等研究院,上海201210 [2]上海科技大学信息科学与技术学院,上海201210 [3]中国科学院大学,北京100049 [4]上海联影医疗科技有限公司,上海201807 [5]首都医科大学宣武医院放射科,北京100053 [6]磁共振成像脑信息学北京市重点实验室,北京100053 [7]首都医科大学宣武医院核医学科,北京100053

出　　处：《核技术》2020年第5期14-23,共10页Nuclear Techniques

基　　金：国家重点研发计划"数字诊疗装备研发"试点专项(No.2016YFC0103900)资助。

摘　　要：在正电子发射断层成像(Positron Emission Tomography,PET)的临床诊断和科研中,为了减小标准化摄取值(Standard Uptake Value,SUV)在不同受试者间的差异性,通常会以特定的参考区域为基准计算标准化摄取值比(Standard Uptake Value Ratio,SUVR)。由于PET图像无法反应脑部结构信息,从PET图像中无法准确分割出参考区域,从而影响了SUVR的准确性。本文利用一体化正电子发射断层成像/磁共振成像(Positron Emission Tomography-Magnetic Resonance Imaging,PET-MRI)同步采集年龄相近的健康志愿者的PET和MRI数据,基于准确反映脑部结构信息的MRI图像分割出参考区域,映射到对应的PET图像后再进行SUVR的计算,将其与利用PET图像分割参考区域算出的SUVR进行比较。结果显示:利用MRI分割参考区域算出的SUVR变异系数更小,离散程度更低,在相似的健康志愿者间具有更好的一致性,更好地消除了受试者间的个体差异。[Background]In clinical application and scientific research of positron emission tomography(PET),the standard uptake value(SUV)is commonly used for disease assessment.In order to reduce the deviations of SUV among clinical PET images,standard uptake value ratio(SUVR)based on a specific reference region is substituted for SUV.Accurate SUVR is hardly achieved directly from PET images due to the difficulty of accurately segmenting reference regions from PET images with low resolution and high noise.The integrated positron emission tomographymagnetic resonance imaging(PET-MRI)can simultaneously acquire MRI images and PET images,hence the combination of MRI image and PET image is expected to improve the accuracy of SUVR.[Purpose]This paper study aims to investigate the effect of MRI segmentation and PET segmentation on SURV calculation to improve the PET-MRI brain quantitative accuracy.[Methods]First of all,integrated PET-MRI was used to acquire MRI and PET images of 12-age-controlled healthy volunteers simultaneously.Then the MRI images and PET images were segmented into reference regions by the atlas-based method.Based on reference regions derived from MRI and PET respectively,the SUVRs of left/right cerebrum,cerebral cortex,cerebral white matter,frontal lobe,parietal lobe,temporal lobe and occipital lobe were calculated.For each group of SUVRs,the coefficient of variation(CV)of SUVRs was calculated to measure consistency level.Finally,quantitative analysis was performed to evaluate which segmentation method offered better SUVR consistency among volunteers.[Results]CV of SUVRs based on cerebellar gray matter from MRI images and PET images were 0.020/0.021,0.023/0.026,0.031/0.028,0.028/0.031,0.033/0.036,0.022/0.024,0.044/0.045 and 0.052/0.055,0.054/0.055,0.058/0.063,0.053/0.058,0.063/0.065,0.048/0.050,0.059/0.065 respectively.When the cerebellum was chosen as reference region,MRI results and PET results were 0.017/0.019,0.021/0.025,0.029/0.025,0.026/0.030,0.032/0.036,0.020/0.022,0.044/0.045 and 0.046/0.050,0.049/0.05

关 键 词：标准化摄取值比 定量 正电子发射断层成像-磁共振成像 氟代脱氧葡萄糖 

分 类 号：R445[医药卫生—影像医学与核医学] TL99[医药卫生—诊断学]