血脂康对高脂血症患者低密度脂蛋白颗粒和氧化型低密度脂蛋白的影响  

Effects of Xuezhikang on low-density lipoprotein subfractions and oxidized LDL in patients with hyperlipidemia

作　　者：张月 徐瑞霞[1] 张彦[1] 吴亚茹 李建军[1] ZHANG Yue;XU Ruixia;ZHANG Yan;WU Yaru;LI Jianjun(Division of Dyslipidemia,State Key Laboratory of Cardiovascular Disease&Fu Wai Hospital&National Center for Cardiovascular Disease,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China)

机构地区：[1]中国医学科学院北京协和医学院阜外医院,国家心血管病中心,心血管疾病国家重点实验室,北京市100037

出　　处：《中国动脉硬化杂志》2020年第3期229-232,共4页Chinese Journal of Arteriosclerosis

基　　金：北京协和医学院协和青年基金(3332018200);首都卫生发展科研专项项目(2016-1-4035)。

摘　　要：目的探讨血脂康对高脂血症患者低密度脂蛋白(LDL)颗粒和氧化型低密度脂蛋白(ox-LDL)的影响。方法连续入选未服用降脂药物治疗的受试人群40例(其中高脂血症患者20例,健康受试者20例),分为血脂康组(n=20例)和对照组(n=20例)。Lipoprint脂蛋白分类检测仪对LDL颗粒进行分类。治疗8周后比较两组治疗前后LDL颗粒和ox-LDL的变化。结果与治疗前相比,治疗后血脂康组的血清低密度脂蛋白胆固醇(LDLC)、总胆固醇(TC)、甘油三酯(TG)和载脂蛋白B的浓度显著降低(P<0.05),小颗粒LDLC的浓度和小颗粒LDL的百分比均降低(P<0.05)。经血脂康治疗后,ox-LDL的浓度显著降低(P<0.05)。结论血脂康治疗8周可显著改善高脂血症患者的血脂谱,并降低致动脉粥样硬化性小颗粒LDLC浓度和百分比,同时减少氧化应激反应。Aim To investigate the effects of Xuezhikang(XZK)on low-density lipoprotein(LDL)subfractions and oxidized low-density lipoprotein(ox-LDL)in patients with hyperlipidemia.Methods A total of 40 subjects(20 patients with hyperlipidemia and 20 healthy subjects)who were not treated with lipid-lowering drugs were selected consecutively and divided into the XZK group(n=20)and the control group(n=20).The plasma LDL subfractions,ox-LDL were examined by using the Lipoprint system at baseline and again after 8 weeks.Results Data showed that XZK could significantly decrease not only plasma LDLC levels,total cholesterol,triglycerides,and apolipoprotein B(P<0.05),but also ox-LDL(P<0.05).At the same time,XZK reduced the concentration of small LDLC(P<0.05)and the percentage of the small LDL subfraction(P<0.05).Conclusion XZK treatment for 8 weeks significantly improved the blood lipid profile,reduced the concentration and percentage of atherogenic small LDLC,and reduced the level of oxidative stress.

关 键 词：血脂康 高脂血症 低密度脂蛋白颗粒 氧化型低密度脂蛋白 

分 类 号：R5[医药卫生—内科学]