COVID-19心脏损伤的机制及防治策略  

Mechanism and prevention strategy on heart injury of COVID-19

作　　者：曾倩 赵思敏 万恒佺 屈顺林[1] 姜志胜[1] ZENG Qian;ZHAO Simin;WAN Hengquan;QU Shunlin;JIANG Zhisheng(Pathophysiology Department&Institute of Cardiovascular Disease&Key Laboratory for Arteriosclerology of Hunan Province&Hunan International Scientic and Technological Cooperation Base of Arteriosclerotic Disease,University of South China,Hengyangy Hunan 421001,China)

机构地区：[1]南华大学病理生理学教研室,心血管疾病研究所,动脉硬化学湖南省重点实验室,湖南省动脉硬化性疾病国际联合实验室,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2020年第4期301-305,共5页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金(8167042481900424);湖南省卫生计生委项目(B2016087,B20180058,B20180874);湖南省自然科学基金项目(2018JJ2345、2019JJ40258、2019JJ50502和2015JJ2118)。

摘　　要：2019新型冠状病毒(2019-nCoV)以血管紧张素转换酶2(ACE2)为受体侵入细胞引起机体感染,所引起的"细胞因子风暴"是2019冠状病毒病(COVID-19)爆发和死亡的重要原因。临床资料显示,2019-nCoV除了累及呼吸系统外,还伴随着心脏损伤,如急性心肌损伤、心律失常和爆发性心肌炎等。文章主要阐述2019-nCoV对心脏损伤的主要表现和发病机制及其相关防治策略。2019 novel coronavirus(2019-nCoV)invades cells with angiotensin converting enzyme 2(ACE2)as a receptor to cause infection,and the result of"cytokine storm"is the significant reason inducing coronavirus disease 2019(COVID-19)?s outbreak and death.Clinical data shows that 2019-nCoV is not only involved in the respiratory system,but also accompanied by heart injury,such as acute myocardial injury,arrhythmia and fulminant myocarditis.This review mainly describes the main manifestations,mechanism and prevention strategies of heart injury caused by 2019-nCoV.

关 键 词：2019新型冠状病毒 心脏损伤 氧化应激 血管紧张素转换酶2 

分 类 号：R541.9[医药卫生—心血管疾病]