医院开展动物实验中伦理审查和动物福利实施的现状分析  

Current situation analysis of ethical review and implementation of animal welfare about animal experiments in hospitals

作　　者：刘海玲 叶苗苗 陈苑[2] 朱雪琼[1] Liu Hailing;Ye Miaomiao;Chen Yuan;Zhu Xueqiong(Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325027,China;Department of science and education,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325027,China)

机构地区：[1]温州医科大学附属第二医院妇产科,325027 [2]温州医科大学附属第二医院科教科,325027

出　　处：《中华医学科研管理杂志》2020年第1期64-69,共6页Chinese Journal of Medical Science Research Management

摘　　要：目的 通过了解医院开展动物实验时伦理审查、动物福利和动物使用法规实施情况,分析医院开展动物实验的现状及存在的问题,并提出对策.方法 在万方医学数据库中回顾性收集2017年1月-2018年3月发表的文章,以特定检索词和分类方法,分析医院中开展动物实验时的伦理审查现状及存在问题.结果 提及通过动物伦理审查的论文71篇,占9.2%;提及动物福利相关内容的411篇,占53.3%;提及实验动物使用法规的75篇,占9.7%.既提及动物饲养条件又提及动物安乐死方法的文章70篇,占9.6%,而两者均未提及文章有339篇,占46.4%.在提及通过动物伦理审查方面,有基金资助的论文与无基金资助者相比,有显著性差异.在提及实验动物福利方面,有基金资助和无基金资助的论文相比,无明显差异.提及动物使用法规方面,国家级基金资助的论文和非国家级基金资助者相比,有显著性差异.结论 医院开展动物实验时,对动物伦理审查、实验动物的福利保障、有关动物使用法规的实施尚不重视,需不断加强研究者动物保护意识,督促其遵循实验动物福利原则和遵守动物使用法律和法规,进一步规范动物实验的研究.Objective This paper analyzes the situation and problems of animal experiments in hospitals,which including the ethical review,regulatory compliance of animal welfare and animal experimental use,proposing possible measurements for reference.Methods We retrospectively searched Wanfang database,used specific search terms and classification methods to analyze the current situation and problems of ethical review in conducting animal experiment in hospitals.Results In all papers,71 mentioned that the experiment got ethical review approval,accounting for 9.2%;411 mentioned about content of animal welfare,accounting for 53.3%;and 75 referred to the laws and regulations of animal experiments,taking up 9.7%.70(9.6%)papers focused on both feeding conditions and euthanasia.However,339(46.4%)papers did not mention any of them.In reference to the approval of animal welfarecommittee,there was a significant difference between funded papers and non-funded papers.In animal welfare,there was no significant difference between papers with funds or not.In the laws and regulations of animal experiment,there were significant differences between state-funded papers and non-state-funded papers.Conclusions So far,when carrying out animal experiments in hospitals,little attention has been paid to the ethical review,so was to the regulatory compliance of animal welfare and animal experimental use.Researchers should constantly strengthen their awareness of animal protection,make sure compliance with the welfare principles of experimental animals,animal protection laws and regulations,and further standardize animal research.

关 键 词：动物福利 动物伦理 动物实验 医院 基金 

分 类 号：R197.32[医药卫生—卫生事业管理]