围绝经期功能性子宫出血采用去氧孕烯炔雌醇(妈富隆)联合小剂量米非司酮治疗的临床疗效观察  

Clinical observation of perimenopausal dysfunctional blood treated with deoxypregnene ethynestradiol(Marvelon) and low dose mifepristone

作　　者：张世应[1] 孙绪举[1] ZHANG Shi-Ying;SUN Xu-Ju(Liyuan Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430077,China)

机构地区：[1]华中科技大学同济医学院附属梨园医院药学部,湖北武汉430077

出　　处：《中国妇幼保健》2020年第9期1686-1689,共4页Maternal and Child Health Care of China

基　　金：湖北省自然科学基金(2016CFB646)。

摘　　要：目的观察围绝经期功能性子宫出血采用去氧孕烯炔雌醇(妈富隆)联合小剂量米非司酮治疗的临床疗效。方法研究对象选定为106例在华中科技大学同济医学院附属梨园医院接受功能性子宫出血治疗的围绝经期患者,入院时间为2018年1月-2018年12月,分组方法为:随机数字法,每组各53例,接受刮宫+妈富隆治疗的为对照组,观察组患者诊断性刮宫后第3天开始给予米非司酮,其余治疗方案同对照组。观察两组患者出血时间、控制出血时间,两组患者治疗前后血清激素水平,治疗3个疗程后子宫内膜厚度以及临床疗效。结果观察组患者止血时间和控制出血时间均明显低于对照组,差异有统计学意义(P<0. 05),两组患者治疗前LH、P、E2、FSH水平差异均无统计学意义(均P>0. 05),治疗后两组患者上述指标与本组治疗前相比均明显降低,差异有统计学意义(P<0. 05),但观察组患者治疗后上述指标均低于对照组,组间差异有统计学意义(P<0. 05),两组患者子宫治疗前子宫内膜厚度差异无统计学意义(P>0. 05),治疗后与治疗前相比子宫内膜厚度均明显减少(P<0. 05),但观察组患者明显低于对照组,差异有统计学意义(P<0. 05),观察组治疗总有效率为98. 11%,明显高于对照组86. 79%,差异有统计学意义(P<0. 05)。结论围绝经期功能性子宫出血采用妈富隆联合小剂量米非司酮治疗具有很好的临床疗效。Objective To observe the clinical efficacy of deoxypregnene ethinylestradiol(Marvelon) combined with low dose mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding.Methods 106 perimenopausal patients with functional uterine bleeding from January 2018 to December 2018 were selected for clinical study.The patients were divided into observation group and control group by random number method,53 cases in each group.The patients in control group were treated with curettage,and the patients in control group were treated with deoxypregnene ethinylestradiol tablets(Marvelon) after curettage.Mifepristone was given to the patients in the observation group on the 3 rd day after diagnostic curettage.The rest of the treatments were the same as those in the control group.The bleeding time and bleeding control time of the two groups were observed.Serum hormone levels,endometrial thickness and clinical efficacy of the two groups before and after treatment were observed.Results The hemostasis time and hemorrhage control time in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in the levels of LH,P,E2 and FSH between the two groups before treatment(P>0.05).After treatment,the above indexes in the two groups were significantly lower than those before treatment,with statistical difference.(P<0.05),but after treatment,the above indexes in the observation group were lower than those in the control group,with significant difference between the two groups(P<0.05).There was no significant difference in endometrial thickness between the two groups before treatment(P>0.05).After treatment,the endometrial thickness in the observation group was significantly lower than that in the control group(P<0.05),but significantly lower than that in the observation group(P<0.05).The total effective rate of the observation group was 98.11%,which was significantly higher than that of the control group(86.79%,P< 0.05).Conclusion Deoxypregnene ethinylestradio

关 键 词：围绝经期 功能性子宫出血 米非司酮 去氧孕烯炔雌醇 

分 类 号：R711.52[医药卫生—妇产科学]