2013-2017年攀枝花市HIV抗体阳性者流行特征及WB带型分析  

Epidemiological characteristics and band patterns of Western bolt in HIV antibody positive individuals from Panzhihua city, 2013-2017

作　　者：潘泓宇[1] 陈鑫莹[1] 李春霞[1] 夏云[1] 吴万里[1] 封正娟 PAN Hong-yu;CHEN Xin-ying;LI Chun-xia;XIA Yun;WU Wan-li;FENG Zheng-juan(Panzhihua Center for Disease Control and Prevention,Panzhihua,Sichuan 617000,China)

机构地区：[1]四川省攀枝花市疾病预防控制中心,四川攀枝花617000

出　　处：《热带医学杂志》2020年第2期261-263,274,共4页Journal of Tropical Medicine

摘　　要：目的分析2013-2017年攀枝花市人免疫缺陷病毒(HIV)抗体阳性者流行特征及Western bolt(WB)带型,为艾滋病的精准防控提供科学依据。方法收集并分析HIV抗体阳性者的性别、年龄、职业、婚姻状况、文化程度等信息,采用蛋白免疫印迹试验进行检测。结果 2013-2017年共检测到2 818例HIV阳性者,其中男性2 057例,女性761例,年龄中位数42岁,大多数为农民(38.89%),不同年份HIV阳性者的年龄、职业、文化程度、婚姻状况的差异有统计学意义(P<0.05)。抗env基因编码的包膜蛋白抗体检出率最高,抗pol基因编码的抗体检出率次之,抗gag基因编码的核心蛋白抗体检出率最低。不同性别各WB带型分布差异无统计学意义(P>0.05),gp160、P66、P31、P24、P17、P55带型在不同年龄组的检出率差异有统计学意义(P<0.05)。结论攀枝花市HIV阳性者主要为中老年文化程度较低的已婚农民,需要针对重点人群精准防控。Objective To explore epidemiological characteristics and band patterns of Western bolt(WB) in human immunodeficiency virus(HIV)antibody positive individuals,which will provide scientific information for AIDS control and prevention in Panzhihua city. Methods Data on HIV antibody positive individuals including gender,age,occupation,marital status and educational background were collected and analyzed using R 3.5.0. HIV antibodies were detected with Western bolt method. Results A total of 2 818 HIV antibody positive individuals were identified from 2013 to 2017 by the Panzhihua Center for Diseases Control and Prevention. Of these,2 057 were male and 761 were female. The median age was42 years old and most individuals were low-educated,married farmers(38.89%). However,epidemiological characteristics of individuals from different years were significantly different(P<0.05). The detection rate of env gene was the highest,followed by pol gene and the detection rate of gag gene was the lowest. The difference of WB pattern between different gender group was not significant(P>0.05),but the detection rates of gp160,P66,P31,P24,P17 and P55 were significantly different(P<0.05). Conclusion The majority of HIV antibody positive individuals of Panzhihua city were male,elderly,low-educated and married farmers,but accurate measures should be conducted for the key populations.

关 键 词：HIV 抗体阳性 WB带型 

分 类 号：R512.91[医药卫生—内科学]