痤疮丙酸杆菌的新命名及其与寻常痤疮的相关性  

Propionibacterium acnes:renaming and its correlation with acne vulgaris

作　　者：郎德休 廖勇 杨蓉娅 Lang Dexiu;Liao Yong;Yang Rongya(Department of Dermatology,The Seventh Medical Center of PLA General Hospital,Beijing 100700,China)

机构地区：[1]解放军总医院第七医学中心皮肤科,北京100700

出　　处：《中华皮肤科杂志》2020年第5期394-397,共4页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81571972);北京市科技新星计划项目(Z161100004916139)。

摘　　要：近来,有研究者建议将痤疮丙酸杆菌命名为Cutibacterium acnes(C.acnes),以更好研究其分型并与其他丙酸杆菌区分。C.acnes是人类皮肤重要的定植菌,参与维持皮肤健康,但也可能转变成为寻常痤疮的机会性病原菌。最新的研究显示,C.acnes不同型别间的平衡和与其他微生物的相互作用在寻常痤疮发生发展中发挥关键作用。本文综述C.acnes分型及其与寻常痤疮的相关性、药物敏感性和与其他微生物的相互作用。Recently,biochemical and genomic studies have specified new classification methods and renamed Propionibacterium acnes as Cutibacterium acnes(C.acnes)to better study its phylotypes and distinguish it from other Propionibacterium species.C.acnes,an important commensal bacterium in human skin,is involved in maintaining skin health,and can also turn into an opportunistic pathogen causing acne vulgaris.Latest studies have showed that the balance between different phylotypes of C.acnes and its interaction with other microorganisms play a key role in the occurrence and development of acne vulgaris.This review summarizes correlations between C.acnes phylotypes and acne vulgaris,as well as antimicrobial susceptibility and interaction with other microorganism of C.acnes.

关 键 词：寻常痤疮 痤疮丙酸杆菌 细菌分型技术 抗药性 细菌 微生物相互作用 表皮葡萄球菌 细菌噬菌体 Cutibacterium acnes 

分 类 号：R75[医药卫生—皮肤病学与性病学]