布比卡因在全身麻醉吸脂肿胀液的使用和安全性评估  

Application and safety of bupivacaine undergoing tumescent liposuction in general anesthesia

作　　者：齐越 王晓媛 QI Yue;Wang Xiaoyuan(Plastic Surgery Hospital,Chinese Academy of Medical Science,Beijing 100041,China;Beijing Alus Medical Beauty Clinic,Beijing 100082,China)

机构地区：[1]中国医学科学院北京协和医学院整形外科医院体形雕塑吸脂中心,北京100041 [2]北京阿露丝医疗美容门诊部,100082

出　　处：《中华医学美学美容杂志》2020年第1期40-42,共3页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：中国医学科学院科研项目(2016RC310008)。

摘　　要：目的探讨布比卡因肿胀液在全身麻醉吸脂术安全性及有效性。方法2015年3月至2017年12月,收集女性吸脂患者149例资料,年龄18~63岁,平均28.9岁。在全身麻醉结合含布比卡因局部麻醉肿胀液作用下完成不同部位吸脂术。结果布比卡因使用量1.14~1.87 mg/kg未显示明显毒性,布比卡因联合利多卡因组在所试各种吸脂量范围未显示不良反应。布比卡因组及其布比卡因联合利多卡因组肿胀液镇痛效果优于利多卡因组,术后当天无明显疼痛感,而利多卡因组肿胀液术后当天疼痛感明显;布比卡因组患者术后住院时间比利多卡因组患者缩短一半;使用含布比卡因的肿胀液术后患者恢复快、愈合好、并发症少。结论布比卡因及其布比卡因联合利多卡因肿胀液具有镇痛时间长、麻醉效果好、术后无痛苦等优点,值得临床应用。Objective To explore the safety,composition and effectiveness of bupivacaine in swelling fluid and to understand the safe use of the swelling fluids contained bupivacaine as local anesthetics in liposuction.Methods The liposuction was completed in 149 patients,aged 18-63 years with the swelling fluid contained bupivacaine in different proportions by negative pressure liposuction for exploring the method and safe use of the swelling fluid contained bupivacaine in general anesthesia.Results The dose range of bupivacaine at 1.14-1.87 mg/kg did not show toxicity.Bupivacaine combined with lidocaine as a part of swelling fluid was suitable for all range of liposuction in general anesthesia.There was no pain sensation first day after the operation.The pain was obvious on the day after surgery in lidocaine group.The advantage using bupivacaine as swelling fluid was that the postoperative recovery was fast,the healing was good,and the complications were few.Conclusions Bupivacaine as the main anesthetic agent for swelling fluid shows the advantages of long analgesic effect,good anesthetic effect,and no pain after operation.It is worth further application.

关 键 词：布比卡因 利多卡因 安全 吸脂 肿胀液 

分 类 号：R614[医药卫生—麻醉学]