Removal of biofilm is essential for long-term ventilation tuberetention  

作　　者：Qiang Ma Hui Wang Zheng-Nong Chen Ya-Qin Wu Dong-Zhen Yu Peng-Jun Wang Hai-Bo Shi Kai-Ming Su 

机构地区：[1]Department of Otorhinolaryngology–Head&Neck Surgery,the Sixth People’s Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233,China [2]Shanghai Key Laboratory of Sleep Disordered Breathing,Shanghai 200233,China

出　　处：《World Journal of Clinical Cases》2020年第9期1592-1599,共8页世界临床病例杂志

基　　金：Supported by Shanghai Leadership Talent Training Plan,No. 2017062;the Key Project of Shanghai Jiao Tong University Medicine Science and Engineering Interdisciplinary Foundation,No. YG2016ZD02;Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support,No.20152233;Multi-Center Clinical Research Plan of Medical College of Shanghai Jiao Tong University,No. DLY201823;the Clinical Research Plan of Shanghai Shen Kang Hospital Development Center,No. 16CR4022A and No.16CR3041A;National Natural Science Foundation of China,No.81974142.

摘　　要：BACKGROUND Although long-term retention of a ventilation tube is required in many ear diseases,spontaneous removal of conventional ventilation tube is observed in patients within 3 to 12 mo.To address this issue,we aimed to determine a new method for long-term retention of the ventilation tube.AIM To explore the value of removing the biofilm for long-term retention of tympanostomy ventilation tubes.METHODS A case-control study design was used to evaluate the safety and effectiveness of long-term tube retention by directly removing the biofilm(via surgical exfoliation)in patients who underwent myringotomy with ventilation tube placement.The patients were randomly divided into two groups:Control group and treatment group.Patients in the treatment group underwent regular biofilm exfoliation surgery in the clinic,whereas those in the control group did not have their biofilm removed.Only conventional ventilation tubes were placed in this study.Outcome measures were tube position and patency.Tube retention time and any complications were documented.RESULTS Eight patients with biofilm removal and eight patients without biofilm removal as a control group were enrolled in the study.The tympanostomy tube retention time was significantly longer in the treatment group(43.5±26.4 mo)than in the control group(9.5±6.9 mo)(P=0.003).More tympanostomy tubes were found to be patent and in correct position in the treatment group during the follow-up intervals than in the control group(P=0.01).CONCLUSION Despite the use of short-term ventilation tubes,direct biofilm removal can be a well-tolerated and effective treatment for long-term tube retention of tympanostomy ventilation tubes in patients who underwent myringotomy.

关 键 词：Tympanostomy tubes BIOFILM COMPLICATION management LONG-TERM RETENTION Ménière disease Refractory OTITIS media with EFFUSION 

分 类 号：R764.9[医药卫生—耳鼻咽喉科]