骨膜在骨折愈合及骨组织修复过程中的作用  

Role of periosteum in fracture healing and bone tissue repair

作　　者：蒋昇源 宫智浩 宋凯凯 杜刚强[1] 李朋[1] 张锴[1] Jiang Shengyuan;Gong Zhihao;Song Kaikai;Du Gangqiang;Li Peng;Zhang Kai(Department of Traumatic Orthopedics,Binzhou Medical University Hospital,Binzhou 256600,Shandong Province,China)

机构地区：[1]滨州医学院附属医院创伤骨科,山东省滨州市256600

出　　处：《中国组织工程研究》2020年第30期4860-4865,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:骨膜因含有成骨潜能的细胞而参与骨折愈合及骨组织修复的过程,其在修复骨缺损方面的作用是目前研究的热点。目的:对骨膜在骨折愈合及骨组织修复过程中所发挥的作用进行综述。方法:第一作者应用计算机检索1964年1月至2019年12月PubMed、中国知网数据库等中英文期刊全文数据库有关骨膜在骨折愈合及骨组织修复过程中作用的文章,英文检索词"periosteum,bone healing,periosteum cells";中文检索词"骨膜,骨折愈合,骨膜细胞"。最终选择48篇重要文献进行综述。结果与结论:①骨膜的完整性对于骨折愈合和骨组织的修复极其重要,因其较好的成骨性能、优质的材料学特性和屏障作用等特点被广泛应用于骨组织工程;②骨膜在牵拉成骨过程中的作用机制目前尚且存在争议,研究证实骨膜缺如并不会影响下颌骨缺损牵拉成骨的效果,但在四肢骨缺损牵拉成骨中的作用仍有待进一步研究。BACKGROUND: The periosteum is involved in fracture healing and bone tissue repair because it contains cells with osteogenic potential, and its role in repairing bone defects has become a focus of current research. OBJECTIVE: To review the role of periosteum in fracture healing and bone tissue repair. METHODS: A computer-based online search of China National Knowledge Infrastructure database and PubMed was performed for articles regarding the role of periosteum in fracture healing and bone tissue repair published from January 1964 to December 2019. Key words included "periosteum, bone healing, periosteum cells" in English and Chinese. Finally, a total of 48 articles were included to review. RESULTS AND CONCLUSION:(1) The integrity of periosteum plays an important role in fracture healing and bone tissue repair, and has been widely used in bone tissue engineering due to its good osteogenic properties, excellent material properties and barrier effect.(2) The mechanism of periosteum in the process of distraction ostegogenesis is still controversial. It has been confirmed that absence of periosteum does not affect the osteogenic effect of mandibular defects, but the role of periosteum in osteogenic effect of limb defects remains to be further studied.

关 键 词：骨 骨折 骨膜 骨膜细胞 成骨 骨缺损 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]