AT-hook蛋白的最新研究进展  

The Latest Research Progress of AT-hook Protein

作　　者：王元元 刘姣[2] 郭育强 王硕 符少萍[2] 段瑞军[2] 李瑞梅[2] 姚远[2] 胡新文 郭建春[2] Wang Yuanyuan;Liu Jiao;Guo Yuqiang;Wang Shuo;Fu Shaoping;Duan Ruijun;Li Ruimei;Yao Yuan;Hu Xinwen;Guo Jianchun(College of Agriculture,Hainan University,Haikou,570288;Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agriculture Sciences,Haikou,571101)

机构地区：[1]海南大学热带农林学院,海口570228 [2]中国热带农业科学院热带生物技术研究所,农业部热带作物生物学与遗传资源利用重点实验室,海口571101

出　　处：《基因组学与应用生物学》2020年第2期713-717,共5页Genomics and Applied Biology

基　　金：中国科协青年人才托举工程项目(2015QNRC001);国家自然科学基金(31371706);国家现代农业产业技术体系建设专项(CARS-11-HNGJC)共同资助。

摘　　要：AT-hook是一类新的DNA结合蛋白基序,与其他功能已知的DNA结合蛋白基序不同。AT-hook蛋白具有AT-hook基序和PPC(plants and prokaryotes conserved domain,DUF296)两个特殊功能域。AT-hook广泛存在于不同物种的DNA结合蛋白中,在植物生长发育、器官构建、逆境胁迫和激素信号应答中发挥重要的调节作用;对基因克隆、细胞间特异性结合、染色体结构调节以及转录因子调节具有重要的调控作用。通过调节AT-hook蛋白进而改变生物某些不理想的生理生化调控通路,提高生物某些优良性状具有重要研究价值及意义。本综述主要从AT-hook蛋白的结构特征、分类及其依据、功能调节机制、生物学功能以及研究价值等方面进行相关阐述及总结。AT-hook is a new class of DNA-binding protein motifs that differes from other known DNA-binding protein motifs.AT-hook protein has two special functional domains:AT-hook motif and PPC(plants and prokaryotes conserved domain,DUF296).AT-hook is widely distributed in DNA-binding proteins of different species and plays an important regulatory role in plant growth and development,organ construction,stress and hormone signaling;gene cloning,intercellular specific binding,chromosome structure regulation and transcription factor regulation has an important regulatory role.It is of great research value and significance to improve some excellent traits of organisms by regulating AT-hook protein and then changing some unhealthy physiological and biochemical regulatory pathways.This review mainly elaborates and summarizes the structural characteristics,classification and basis,function regulation mechanism,biological function and research value of AT-hook protein.

关 键 词：AT-hook蛋白 功能机制 研究进展 

分 类 号：Q753[生物学—分子生物学]