胡萝卜苷棕榈酸酯改善阿尔茨海默病大鼠学习记忆障碍的神经保护作用  

Neuroprotective Effect of Daucosterol Palmitate in Ameliorating Learning and Memory Impairment in a Rat Model of Alzheimer’s Disease

作　　者：于秀华 Yu Xiuhua(Shanghai Modem Hasen(Shangqiu)Pharmaceutical Co.,LTD.,Shangqiu,476000)

机构地区：[1]上海现代哈森(商丘)药业有限公司,商丘476000

出　　处：《基因组学与应用生物学》2020年第2期800-805,共6页Genomics and Applied Biology

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是一种与年龄相关的神经退行性疾病,其特征是进行性记忆减退和认知障碍。淀粉样β蛋白(Aβ)被认为是AD发病的致病因素。越来越多的证据表明Aβ神经毒性是由谷氨酸兴奋毒性介导的。胡萝卜苷棕榈酸酯(daucosterol palmitate,DSP)是从抗衰老中草药益智(Alpinia oxyphylla)中分离得到的一种具有抗谷氨酸兴奋毒性作用的植物类固醇。在我们之前的研究中。基于DSP的抗谷氨酸兴奋毒性作用,探讨了DSP改善AD模型大鼠学习记忆障碍的潜在保护作用及其机制。结果表明,DSP能有效改善Aβ诱导的大鼠学习记忆障碍,显著抑制Aβ诱导的海马组织ROS产生,有效地防止Aβ诱导的海马神经元损伤,显著恢复海马突触素的表达水平。这项研究表明,DSP可能是一个开发作为AD认知下降的治疗剂潜在的候选。Alzheimer’s disease(AD)is an age-related neurodegenerative disorder characterized by progressive memory decline and cognitive impairment.Amyloid-β(Aβ)has been proposed as the causative role for the pathogenesis of AD.Accumulating evidence demonstrates that Aβneurotoxicity is mediated by glutamate excitotoxicity.Daucosterol palmitate(DSP),a plant steroid with anti-glutamate excitotoxicity effect,was isolated from the antiaging traditional Chinese medicinal herb Alpinia oxyphylla Miq.in our previous study.Based on the anti-glutamate excitotoxicity effect of DSP,in this study we investigated potential benefit and mechanism of DSP in ameliorating learning and memory impairment in AD model rats.The results showed that DSP administration effectively ameliorated Aβ-induced learning and memory impairment in rats,markedly inhibited Aβ-induced hippocampal ROS production,effectively prevented Aβ-induced hippocampal neuronal damage and significantly restored hippocampal synaptophysin expression level.This study suggests that DSP may be a potential candidate for development as a therapeutic agent for AD cognitive decline.

关 键 词：益智(Alpinia oxyphylla) 胡萝卜苷棕榈酸酯 阿尔茨海默病 学习记忆 

分 类 号：R285.5[医药卫生—中药学]