人参及人参皂苷治疗风湿性疾病的研究进展  

Research progress of ginseng and ginsenoside in the treatment of rheumatic diseases

作　　者：韩广弢 李皓桓[1] HAN Guangtao;LI Haohuan(Department of Orthopedics,Renmin Hospital of Wuhan University,Hubei Province,Wuhan430060,China)

机构地区：[1]武汉大学人民医院骨科,湖北武汉430060

出　　处：《中国医药导报》2020年第10期38-41,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81171760);湖北省自然科学基金项目(2017CFB700)。

摘　　要：炎症可保护人体免受细胞变化引起的病原体和危险信号的损伤。尽管炎症是一种宿主防御机制,但是慢性炎症被认为是发展各种炎性自身免疫疾病的主要危险因素。风湿性疾病是全身性炎性和退化性疾病,其主要影响结缔组织,可导致严重的慢性结缔组织炎症,最终导致结缔组织的退变。人参及人参皂苷已被证明通过抑制炎症介质的表达和产生,对多种风湿性疾病具有抗炎活性和药理作用。本文对人参及人参皂苷进行简要概述,并讨论了最近研究其在风湿性疾病发病机制中的药理作用。这些见解可能会促进人参及人参皂苷类的药物发展,以预防和治疗风湿性疾病。Inflammation protects the body from pathogens and danger signals caused by cellular changes. Although inflammation is a host defense mechanism, chronic inflammation is considered a major risk factor for the development of various inflammatory autoimmune diseases. Rheumatic diseases are systemic inflammatory and degenerative diseases,which mainly affect connective tissue and can lead to severe chronic connective tissue inflammation, ultimately leading to the degeneration of connective tissue. Ginseng and its ginsenoside have been proved to have anti-inflammatory activities and pharmacological effects on a variety of rheumatic diseases by inhibiting the expression and production of inflammatory mediators. This review gives a brief overview of ginseng and ginsenoside, and discusses recent studies on their pharmacological effects on the pathogenesis of rheumatic diseases. These insights may facilitate the development of ginseng and ginsenoside drugs to prevent and treat rheumatic diseases.

关 键 词：人参 人参皂苷 炎症 巨噬细胞 风湿性疾病 

分 类 号：R593.21[医药卫生—内科学]