曲美他嗪治疗高血压性心脏病的临床效果  

Clinical effect of Trimetazidine in the treatment of hypertensive heart dis-ease

作　　者：阳慧[1] 钟江华[1] 苏雨江[1] 马添翼[1] YANG Hui;ZHONG Jianghua;SU Yujiang;MA Tianyi(Department of Cardiovascular Medicine,Haikou People′s Hospital(Haikou Hospital Affiliated to Xiangya Hospital,Central South University),Hainan Province,Haikou 570208,China)

机构地区：[1]海口市人民医院(中南大学湘雅医学院附属海口医院心血管内科),海南海口570208

出　　处：《中国医药导报》2020年第10期149-152,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81660057)。

摘　　要：目的旨在研究曲美他嗪治疗高血压性心脏病的临床效果。方法选取中南大学湘雅医学院附属海口医院接诊的80例高血压性心脏病患者作为研究对象,根据随机数字表法将其分为实验组和常规组,每组各40例。常规组采用常规疗法治疗,实验组在常规组治疗基础上辅以曲美他嗪片进行共同治疗,曲美他嗪片的使用量为20 mg/次,3次/d,两组患者都进行为期3个月的治疗。比较两组患者的临床治疗效果、临床症状、心脏功能变化以及不良症状。结果治疗后,实验组整体生效率高于常规组,差异有统计学意义(P <0.05)。治疗后,实验组心绞痛出现次数、心绞痛的发病持续时间、硝酸甘油使用量均低于常规组,7 min运动量高于常规组,差异均有统计学意义(均P <0.05)。治疗前,两组患者左心室射血分数(LVEF)、左室收缩末期容积指数(LVESVI)、左室舒张末期容积指数(LVEDVI)比较,差异无统计学意义(P> 0.05);治疗后,两组患者LVEF高于治疗前,LVESVI、LVEDVI低于治疗前,且实验组LVEF高于对常规组,LVESVI、LVEDVI低于常规组,差异均有统计学意义(均P <0.05)。治疗期间,两组患者不良症状发生率比较,差异无统计学意义(P> 0.05)。结论在常规药物治疗的基础上使用曲美他嗪,能够显著增加高血压心脏病患者的治疗效果,能够明显降低心绞痛病情的发作次数和硝酸甘油的使用剂量,能够在控制血压的前提下,使患者的心脏功能及运动量得到提升,从而改善患者的预后。Objective To study the clinical effect of Trimetazidine in the treatment of hypertensive heart disease.Methods A total of 80 patients with hypertensive heart disease admitted to Haikou Hospital Affiliated to Xiangya Hospital Central South University were selected as the research object. According to the random number table method, they were divided into experimental group and routine group, with 40 cases in each group. The conventional group was treated with conventional therapy, and the experimental group was treated with Trimetazidine Tablets on the basis of the conventional group. The dosage of Trimetazidine Tablets was 20 mg/time, 3 times/day, and the patients in both groups were treated for 3 months. Clinical treatment effect, clinical symptoms, cardiac function changes and adverse symptoms were compared between the two groups. Results After treatment, the overall productivity of the experimental group was higher than that of the conventional group, and the difference was statistically significant(P < 0.05). After treatment,the frequency of angina pectoris, the duration of angina pectoris and the amount of nitroglycerin used in the experimental group were all lower than those in the conventional group, and the amount of exercise for 7 min was higher than that in the conventional group, with statistically significant differences(all P < 0.05). Before treatment, there was no statistically significant difference in left ventricular ejection fraction(LVEF), left ventricular end-systolic volume index(LVESVI) and left ventricular end-diastolic volume index(LVEDVI) between the two groups(P > 0.05). After treatment,LVEF in the two groups was higher than that before treatment, LVESVI and LVEDVI were lower than those before treatment, and LVEF in the experimental group was higher than that in the conventional group, and LVESVI and LVEDVI were lower than those in the conventional group, with statistically significant differences(all P <0.05). During the treatment period, there was no statistically significant differenc

关 键 词：硝酸甘油 曲美他嗪 心绞痛 高血压性心脏病 

分 类 号：R541.3[医药卫生—心血管疾病]