杜仲化学成分的主要影响因素概况  

Research on the main factors affecting the chemical composition of Eucommia ulmoides Oliv

作　　者：刘锟 潘颖宜[1] 王健英[2] 陈晓云[3] 袁颖[1] LIU Kun;PAN YingYi;WANG Jianying;CHENG Xiaoyun;YUAN Ying(School of Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Collaborative Innovation Center,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Rheumatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学中药学院,上海201203 [2]上海中医药大学协同创新中心,上海201203 [3]上海中医药大学附属龙华医院风湿免疫科,上海200032

出　　处：《中国医药导报》2020年第12期41-44,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81773922);上海中医药大学预算内课题(2016YSN10);上海中医药大学中青年骨干教师教学能力提升资助计划项目。

摘　　要：本文从杜仲不同药用部位、炮制、产地、采收期、血清药物代谢等因素对杜仲化学成分予以综述。发现杜仲不同部位对其化学成分的影响主要体现在有效成分含量的巨大差异,且各部位各具代表性成分;产地采收期的影响也主要表现为化学成分的含量差异明显;而炮制主要改变杜仲化学成分的结构及种类配比关系;血清药物代谢后杜仲化学成分仍为原型,但各成分的药代动力学特征差异较大。本文还结合5个主要影响因素对相关药效进行阐述,可在一定程度上为解释杜仲发挥不同药效作用的物质基础提供参考,也可为杜仲的临床应用和资源开发提供参考。This article reviews the chemical composition of Eucommia ulmoides Oliv. from different medicinal parts,processing methods, producing area, collection time and serum drug metabolism. It is found that the influence of different medicinal parts of Eucommia ulmoides Oliv. on the chemical composition is mainly reflected in the great difference in the content of effective components and the representative components of each part. The influence of collection time in producing area is mainly manifested in the obvious difference of chemical composition content. The processing methods of Eucommia ulmoides Oliv. mainly changes the structure of its chemical composition and the ratio of its species. The chemical components of Eucommia ulmoides Oliv. are still prototype after drug metabolism, but the pharmacokinetic characteristics of each component are quite different. This article also combines five main influencing factors to elaborate the relevant drug effects. It may provide a reference to explain the material basis of Eucommia ulmoides Oliv. exerting different drug effects to a certain extent, and may also provide a reference for the clinical application and resource development of Eucommia ulmoides Oliv..

关 键 词：杜仲 化学成分 药用部位 炮制 产地 采收期 药物血清 

分 类 号：R285.5[医药卫生—中药学]