光动力联合自制中药方剂浸泡治疗跖疣的效果及对患者血清TGF-β、IFN-γ、CD28及CD40水平的影响  

Effect of photodynamic therapy combined with self-made traditional Chinese medicine in the treatment of verruca plantaris and its influence on the levels of serum TGF-β, IFN-γ, CD28 and CD40 in patients

作　　者：孙焱[1] SUN Yan(Department of Dermatology and Venereology,the People′s Hospital of Langfang City,Hebei Province,Langfang 068000,China)

机构地区：[1]河北省廊坊市人民医院皮肤性病科,河北廊坊068000

出　　处：《中国医药导报》2020年第12期192-196,共5页China Medical Herald

基　　金：河北省廊坊市科技计划项目(2016013012)。

摘　　要：目的观察光动力联合自制中药方剂浸泡治疗跖疣的效果及对患者血清转化生长因子-β(TGF-β)、γ-干扰素(IFN-γ)、白细胞表面分化抗原28(CD28)及白细胞表面分化抗原40(CD40)水平的影响。方法选取2018年3月~2019年3月河北省廊坊市人民医院收治的跖疣患者85例,采用抽签方式将其分为对照组(42例)和研究组(43例)。对照组采用光动力治疗,研究组在对照组的基础上采用自制中药方剂浸泡治疗。比较两组治疗前后皮损总面积,评估临床疗效,比较两组治疗前后血清TGF-β、IFN-γ水平及CD28、CD40占比,比较两组副作用、复发情况。结果两组治疗后皮损总面积均小于治疗前,且研究组小于对照组,差异有统计学意义(P <0.05)。研究组临床疗效优于对照组,差异有统计学意义(P <0.05)。两组治疗后血清TGF-β水平低于治疗前,且研究组低于对照组,差异有统计学意义(P <0.05);两组治疗后血清IFN-γ水平高于治疗前,且研究组高于对照组,差异有统计学意义(P <0.05)。两组治疗后血清CD28占比低于治疗前,且研究组低于对照组,差异有统计学意义(P <0.05);两组治疗后血清CD40占比高于治疗前,且研究组高于对照组,差异有统计学意义(P <0.05)。两组副作用发生率比较差异无统计学意义(P> 0.05)。随访3个月,研究组复发率低于对照组,差异有统计学意义(P <0.05)。结论光动力联合自制中药方剂浸泡治疗跖疣,可缩小皮损面积,减轻炎性反应,改善免疫功能,复发率低,疗效明显优于单纯光动力治疗。Objective To observe effect of photodynamic therapy combined with self-made traditional Chinese medicine in the treatment of verruca plantaris and its influence on the levels of serum TGF-β, IFN-γ, CD28 and CD40 in patients. Methods Eighty-five cases of verruca plantaris admitted to Langfang People′s Hospital in Hebei Province from March 2018 to March 2019 were divided into control group(42 cases) and study group(43 cases) by drawing lots.Control group was treated with photodynamic therapy, and study group was treated with self-made traditional Chinese medicine on the basis of control group. Total area of skin lesions before and after treatment was compared between two groups, clinical effect was evaluated, the levels of serum TGF-β, IFN-γ, the proportion of CD28 and CD40 before and after treatment were compared between two groups, and the side effects and recurrence of two groups were compared.Results The total area of skin lesions in two groups after treatment was smaller than that before treatment, and study group was smaller than control group, the differences were statistically significant(P < 0.05). Clinical effect of study group was better than that of control group, the difference was statistically significant(P < 0.05). After treatment, the serum TGF-β level in two groups was lower than that before treatment, which in study group was lower than that in control group, the differences were statistically significant(P < 0.05). After treatment, the serum IFN-γ level of two groups was higher than that before treatment,which of study group was higher than that of control group, the differences were statistically significant(P < 0.05). The percentage of CD28 in two groups after treatment was lower than that before treatment, which in study group was lower than that in control group, the differences were statistically significant(P < 0.05). The percentage of serum CD40 in two groups after treatment was higher than that before treatment, which in study group was higher than that in control group, the diff

关 键 词：光动力 自制中药方剂浸泡 跖疣 转化生长因子-β Γ-干扰素 白细胞表面分化抗原28 白细胞表面分化抗原40 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]