Zyxin蛋白在细胞中的功能及其研究进展  

Zyxin protein function in cells and its research progress

作　　者：岳试超 曹雅倩 YUE Shi-chao;CAO Ya-qian(Medical Research Institute,Wuhan University,Wuhan 430000,China)

机构地区：[1]武汉大学医学研究院,武汉430000

出　　处：《湖北农业科学》2020年第4期13-17,共5页Hubei Agricultural Sciences

摘　　要：Zyxin蛋白是黏着斑蛋白复合物中的重要成员,黏着斑是在细胞中发现的高度动态的多蛋白复合物,其能够传播从细胞外基质到细胞核的信号。Zyxin蛋白具有富含脯氨酸结构域、核输出信号和LIM基序的3个拷贝。近年来的研究表明,Zyxin蛋白不仅在与肌动蛋白相关的生物过程中发挥功能,而且在细胞迁移、细胞黏着、细胞生长、DNA损伤修复、肿瘤生长、天然免疫中也发挥着重要的作用。主要对Zyxin蛋白在细胞中的功能作用以及最新的研究进展进行了综述。Zyxin protein is an important member of the focal adhesion protein complex, which is a highly dynamic multiprotein complex found in cells. It is capable of transmitting signals from the extracellular matrix to the nucleus. Zyxin protein has a broad proline-rich domain, a nuclear export signal and three copies of the LIM motif. Recent studies have shown that Zyxin protein not only functions in actin-related biological processes, but also plays an important role in cell migration, cell adhesion, cell growth, DNA damage repair, tumor growth, and natural immunity. The function of Zyxin protein mainly in cells and the latest research progress was described.

关 键 词：Zyxin蛋白 DNA损伤修复 肌动蛋白调控 免疫 肿瘤 

分 类 号：Q51[生物学—生物化学]