唑来膦酸注射液联合碳酸钙D3片治疗老年女性骨质疏松症的疗效观察  

Efficacy of Zoledronic Acid Injection Combined with Calcium Carbonate D3 Tablets in the Treatment of Osteoporosis in Elderly Women

作　　者：赵静[1] 邰敏歌 苗伟 任艳飞 ZHAO Jing;TAI Minge;MIAO Wei;REN Yanfei(Dept.of Endocrinology,Chifeng Hospital,Inner Mongolia Chifeng 024000,China)

机构地区：[1]赤峰市医院内分泌科,内蒙古赤峰024000

出　　处：《中国医院用药评价与分析》2020年第3期308-311,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨唑来膦酸注射液联合碳酸钙D3片治疗老年女性骨质疏松症的临床疗效。方法:以2013年1月至2018年5月赤峰市医院收治的老年女性骨质疏松症患者192例作为研究对象,采用随机数字表分为唑来膦酸组(给予唑来膦酸注射液治疗)、碳酸钙D3组(给予碳酸钙D3片治疗)及联合用药组(给予唑来膦酸注射液联合碳酸钙D3片治疗),每组64例。比较三组患者治疗前后血磷和血钙的含量、骨密度(包括Ward三角区、股骨大转子、股骨颈和腰椎L2—4骨密度)、骨代谢相关生化指标[骨特异性碱性磷酸酶(BAP)、骨钙素(BGP)、人抗酒石酸酸性磷酸酶5b(TRAP-5b)和Ⅰ型胶原羟基端肽β降解产物(β-CTX)]含量及临床疗效的差异。结果:随着时间迁移,三组患者血磷、血钙、BAP及BGP含量,股骨大转子、股骨颈及腰椎L2—4骨密度呈显著升高趋势;而TRAP-5b、β-CTX含量呈显著降低趋势。治疗后,三组患者血磷、血钙、BAP、BGP、TRAP-5b及β-CTX含量,股骨大转子、股骨颈及腰椎L2—4骨密度的差异均有统计学意义(P<0.05)。治疗后,联合组患者血磷、血钙、BAP及BGP含量,股骨大转子、股骨颈及腰椎L2—4骨密度明显高于唑来膦酸组和碳酸钙D3组,TRAP-5b含量明显低于唑来膦酸组和碳酸钙D3组,差异均有统计学意义(P<0.05)。联合组患者的总有效率为92.19%(59/64),明显优于唑来膦酸组的79.69%(51/64)和碳酸钙D3组的78.13%(50/64),差异均有统计学意义(P<0.05)。结论:唑来膦酸注射液和碳酸钙D3片对老年女性骨质疏松症有一定的疗效,二者联合治疗的效果更好。OBJECTIVE:To probe into the clinical efficacy of zoledronic acid injection combined with Calcium carbonate D3 tablets in the treatment of osteoporosis in elderly women.METHODS:Totally 192 elderly patients with osteoporosis admitted into Chifeng Hospital from Jan.2013 to May 2018 were extracted to divide into the zoledronic acid injection group(with the treatment of zoledronic acid injection),Calcium carbonate D3 tablets group(with the treatment of Calcium carbonate D3 tablets)and combination group(with the treatment of zoledronic acid injection combined with Calcium carbonate D3 tablets)via the random number table,with 64 cases in each group.The level of serum phosphorus and calcium,bone mineral density(including the Ward triangle,the greater trochanter of femur,the neck of femur and lumbar spine L2—4 bone mineral density),bone metabolism related biochemical indicators[bone-specific alkaline phosphatase(BAP)and bone gla protein(BGP),tartrate resistant acid phosphatase 5b(TRAP-5b)and typeⅠcollagen hydroxyl terminal peptideβdegradation products(β-CTX)]before and after treatment and the clinical efficacy of three groups were compared.RESULTS:The levels of blood phosphorus,calcium,BAP,BGP,the greater trochanter of femur,the neck of femur and lumbar spine L2—4 bone mineral density in three groups increased significantly;while the levels of TRAP-5b andβ-CTX decreased significantly.Before and after treatment,the differences in levels of serum phosphorus,calcium,BAP,BGP,TRAP-5b,β-CTX,the greater trochanter of femur,the neck of femur and lumbar spine L2—4 bone mineral density were statistically significant(P<0.05).After treatment,the levels of serum phosphorus,calcium,BAP and BGP,the greater trochanter of femur,the neck of femur and lumbar spine L2—4 bone mineral density in the combination group were significantly higher than those in the zoledronic acid injection group and the Calcium carbonate D3 tablets group,and the level of TRAP-5b was significantly lower than that in the zoledronic acid injection group

关 键 词：唑来膦酸注射液 碳酸钙D3片 骨质疏松症 老年女性 

分 类 号：R97[医药卫生—药品]