808 nm laser triggered self-monitored photo-thermal therapeutic nano-system Y2O3:Nd^3+/Yb^3+/Er^3+@SiO2@Cu2S  

作　　者：ZHIYU ZHANG HAO SUO XIAOQI ZHAO CHONGFENG GUO 

机构地区：[1]National Key Laboratory of Photoelectric Technology and Functional Materials(Culture Base)in Shaanxi Province,National Photoelectric Technology and Functional Materials&Application of Science and Technology International Cooperation Base,Institute of Photonics&Photon-Technology,Northwest University,Xi'an 710069,China

出　　处：《Photonics Research》2020年第1期32-38,共7页光子学研究（英文版）

基　　金：National Natural Science Foundation of China(51672215,11974278)。

摘　　要：A multifunctional photo-thermal therapeutic nano-platform Y2O3:Nd^3+/Yb^3+/Er^3+@SiO2@Cu2S(YR-Si-Cu2S)was designed through a core-shell structure,expressing the function of bio-tissue imaging,real-time temperature detection,and photo-thermal therapy under 808 nm light excitation.In this system,the core Y2O3:Nd^3+/Yb^3+/Er^3+(YR)takes the responsibility of emitting optical information and monitoring temperature,while the shell Cu2S nano-particles carry most of the photo-thermal conversion function.The temperature sensing characteristic was achieved by the fluorescence intensity ratio using the thermally coupled energy levels(TCLs)4S3/2/2H11/2 of Er^3+,and its higher accuracy for real-time temperature measurement in the bio-tissue than that of an infrared thermal camera was also proved by sub-tissue experiments.Furthermore,the photo-thermal effect of the present nano-system Y2O3:Nd^3+/Yb^3+/Er^3+@SiO2@Cu2S was confirmed by Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)ablation.Results indicate that YR-Si-Cu2S has application prospect in temperature-controlled photo-thermal treatment and imaging in bio-tissues.

关 键 词：THERMAL SYSTEM treatment 

分 类 号：R318[医药卫生—生物医学工程] TN249[医药卫生—基础医学]