扶正化痰固本方对早期非小细胞肺癌术后患者免疫功能的影响  

The Influence of Decoction for Strengthening Healthy Qi and Resolving Phlegm and Reinforcing Essence on Immune Function of Postoperative Patients with Early Non-Small Cell Lung Cancer

作　　者：刘冬博 王勋 LIU Dong-bo;WANG Xun(Xinmi First People's Hospital,Xinmi,Henan,China,452370)

机构地区：[1]新密市第一人民医院,河南新密452370

出　　处：《河南中医》2020年第5期755-758,共4页Henan Traditional Chinese Medicine

基　　金：河南省基础与前沿计划项目(112300410030-1)。

摘　　要：目的:观察扶正化痰固本方运用于早期非小细胞肺癌术后的临床疗效及其对患者免疫功能的影响。方法:将70例早期非小细胞肺癌患者按照随机数字表法分为对照组和观察组,每组各35例。两组患者均接受肺癌切除术治疗,对照组术后3周开始接受MVP方案化疗,观察组在对照组的基础上加用扶正化痰固本方治疗。比较两组患者的临床疗效及治疗前后中医证候积分、卡氏评分(karnofsky performance status,KPS)及生活质量评分变化情况。检测两组患者治疗前后免疫功能指标、血清肿瘤标志物[癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原153(carbohydrate antigen 153,CA153)]水平。结果:观察组有效率为91.43%,对照组有效率为71.43%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分低于本组治疗前,且观察组治疗后低于对照组治疗后,差异具有统计学意义(P<0.05)。两组患者治疗后免疫功能指标检测结果低于本组治疗前,且观察组治疗后低于对照组治疗后,差异具有统计学意义(P<0.05)。两组患者治疗后血清CEA、CA153水平低于治疗前,KPS评分、QLQ-C30评分均高于治疗前,且观察组治疗后血清CEA、CA153水平低于对照组,KPS评分、QLQ-C30评分均高于对照组,差异具有统计学意义(P<0.05)。观察组胃肠道反应及骨髓抑制发生率均低于对照组,差异具有统计学意义(P<0.05)。结论:扶正化痰固本方运用于早期肺癌术后,能够有效改善患者免疫功能,减轻毒副反应,提高患者生活质量。Objective:To observe the clinical curative effect and influence of Decoction for Strengthening Healthy Qi and Resolving Phlegm and Reinforcing Essence on immune function of patients with early non-small cell lung cancer.Methods:A total of 70 patients with early non-small cell lung cancer were divided into the control group and the observation group according to the random number table method,with 35 cases in each group.All the patients in the two groups first received lung cancer resection,then the control group began to additionally receive MVP chemotherapy three weeks after surgery,while the observation group was additionally treated with Decoction for Strengthening Healthy Qi and Resolving Phlegm and Reinforcing Essence on the basis of the control group.The clinical effects and the changes of TCM syndrome score,KPS score and quality of life score before and after treatment in the two groups were compared.The immune function indexes,serum tumor markers,including carcinoembryonic antigen(CEA) and carbohydrate antigen 153(CA153) were measured before and after treatment in the two groups.Results:The effective rate was 91.43% in the observation group and 71.43% in the control group,and the difference was statistically significant(P<0.05).After the treatment,the TCM syndrome score of either of the two groups was lower than that of the same group before the treatment,and that of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The test results of immune function indexes of either of the two groups were lower than those of the same group before the treatment,and those of the observation group were lower than those of the control group,and all the differences were statistically significant(P<0.05).The levels of serum CEA and CA153 in the two groups were lower than those before the treatment,KPS score and QLQ-C30 score were higher than those before the treatment,and the levels of serum CEA and CA153 in the observation group were lower than those in t

关 键 词：早期非小细胞肺癌 扶正化痰固本方 MVP方案 化疗 免疫功能 癌胚抗原 糖类抗原153 

分 类 号：R273.342[医药卫生—中西医结合]