血管紧张素转换酶2在高盐诱导肾脏纤维化中的作用  

Role of angiotensin-converting enzyme 2 in high-salt-induced renal fibrosis

作　　者：李玥欣[1] 程锦绣[1] 冯佳莉 钱国玲[1] Li Yuexin;Cheng Jinxiu;Feng Jiali;Qian Guoling(The First Affiliated Hospital of Hebei North University,Zhangjiakou,075000,China)

机构地区：[1]河北北方学院附属第一医院肾内科,河北张家口075000

出　　处：《现代科学仪器》2019年第6期87-89,共3页Modern Scientific Instruments

摘　　要：目的:探讨血管紧张素转换酶2在高盐诱导肾脏纤维化中的作用。方法:抽选本院100例患者,随机分成对照组和观察组,对对照组采用注射血管紧张素抑制剂治疗,观察组采用注射血管紧张素转换酶2治疗,比较两组患者治疗期间肾脏纤维化指标的变化情况。结果:观察组各肾脏纤维细胞SAM、TGF、Smad5、Smad7蛋白表达均明显比对照组少。结论:血管紧张素转换酶2对高盐诱导肾脏具有抗纤维化作用。Objective:To investigate the role of angiotensin-converting enzyme 2 in renal fibrosis induced by high salt.Methods:A total of 100 patients were randomly selected from the control group and the observation group.The control group was treated with angiotensin inhibitor injection.The observation group was treated with angiotensin-converting enzyme 2 injection.The renal fibers of the two groups were compared during treatment Changes in the indicators.Results:The expressions of SAM,TGF,Smad5,and Smad7 in each renal fibroblast in the observation group were significantly lower than those in the control group.CONCLUSION:Angiotensin-converting enzyme 2 has anti-fibrotic effect on kidneys induced by high salt.

关 键 词：血管紧张素转换酶2 高盐诱导 肾脏纤维化 血管紧张素抑制剂 

分 类 号：R54[医药卫生—心血管疾病]