P5P (B6) Focused Genetics, Epigenetic Glance to Health  

作　　者：HaticeSaglam 

机构地区：[1]Eskisehir 26020,Turkey

出　　处：《Journal of US-China Medical Science》2020年第1期1-17,共17页美中医学（英文版）

摘　　要：B6 is a versatile vitamin with many functions and is involved in more than 100 enzymatic reactions.B6 is a term that refers to six compounds that function similarly in the body.The first three are pyridoxamine(PN,an alcohol),pyridoxal(PL,an aldehyde),pyridoxamine(PM)containing an amino group.The corresponding 5′-phosphate esters form the remaining three:pyridoxal5′-phosphate(PLP or P5P),pyridoxine 5′-phosphate(PNP),pyridoxamine 5′-phosphate(PMP).Vitamin B6 must be taken from outside foods.In a healthy body,the liver converts B6 taken from the outside into its active form,P5P.If this transformation is not done in sufficient amounts due to genetic,epigenetic or social reasons,it can cause physiological,psychological and social consequences.In such cases supplementation with P5P may be necessary.Vitamin B6 is found in the structure of proteins and basic compounds in our body,transmitters,erythrocytes and prostaglandins in the nervous system.Vitamin B6 is also important in maintaining hormonal balance and regulating immune system functions.P5P,the body-activated form of vitamin B6,is involved in many reactions,is a part of amino acid synthesis,and others are related to single carbon metabolism,lipid metabolism,glyconeogenesis,heme and neurotransmitter biosynthesis.P5P,aside from functioning as a co-factor,is defined as radical cleaner of reactive oxygen types,a metal chelator and a chaperone in the enzyme folding process.Since it is involved in so many enzymatic reactions,sufficient levels are important to promote and maintain a healthy body.Vitamin B6 is depleted by stress,which can affect your social position,mood,sleep and pain level.In this study,the literature was reviewed by focusing on B6(P5P)and the effects of P5P on chronic inflammatory diseases and other diseases.It was concluded that the use of P5P would be beneficial for the prevention and treatment of these diseases.

关 键 词：Vitamin B6 COENZYME pyridoxal5 phosphate PLP P5P chronic recurrent inflammation vitamin B6 deficiency 

分 类 号：O62[理学—有机化学]