通心络对低氧低压性肺动脉高压大鼠的治疗作用及其机制  

Therapeutic effect and mechanism of Tongxinluo on rats with hypoxic hypobaric pulmonary hypertension

作　　者：王卓[1] 马巧亚[2] 刘宁周 WANG Zhuo;MA Qiaoya;LIU Ningzhou(Department of Traditional Chinese Medicine,Beijing Foreign Studies University Hospital,Beijing 100089,China;Cadres Section,Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,Shaanxi,China;Science and Education,Beijing Chaoyang District Hospital of Chinese Medicine,Beijing 100000,China)

机构地区：[1]北京外国语大学医院中医科,北京100089 [2]西安交通大学第二附属医院干部科,陕西西安710004 [3]北京朝阳区中医院科教科,北京100000

出　　处：《中南医学科学杂志》2020年第3期263-265,共3页Medical Science Journal of Central South China

摘　　要：为探讨通心络治疗低氧低压性肺动脉高压大鼠的效果及其作用机制。选取健康成年SD雄性大鼠随机分为模型组、对照组及通心络组,模型组和通心络组采用低压低氧环境喂养、对照组采用常规环境喂养,通心络组每天给予通心络灌胃,连续干预4周;对比各组大鼠的肺血管重塑指标(WT%、WA%)、肺血流动力学指标(mPAP、RVSP)及NO、ET-1、超氧化物歧化酶(SOD)、丙二醛(MDA)的含量。实验结果显示,通心络降低NO、ET-1水平,对低氧低压性肺动脉高压大鼠具有显著的治疗效果,可以改善氧化应激功能。To explore the effect and mechanism of Tongxinluo in the treatment of hypoxic and hypobaric pulmonary hypertension in rats.Healthy adult SD male rats were randomly divided into model group,control group and Tongxinluo group.The model group and Tongxinluo group were fed with low-pressure hypoxic environment,the control group was fed with regular environment,and the Tongxinlu group was given daily.The rats were intragastrically administrated for 4 weeks.The WT%,WA%,mPAP,RVSP,NO,ET-1,SOD and MDA of each group were compared.The experimental results show that Tongxinluo reduces the levels of NO and ET-1,and has significant therapeutic effects on hypoxic and hypotensive pulmonary hypertension rats,which can improve oxidative stress.

关 键 词：通心络 低氧 低压 肺动脉高压 

分 类 号：R543.2[医药卫生—心血管疾病]