深共熔溶剂-高效液相色谱联用提取测定环境水样中的3种药品和个人护理品  

Determination of three pharmaceuticals and personal care products in water samples by deep eutectic solvents coupled with high performance liquid chromatography

作　　者：黄思聪 饶桂维[1] HUANG Sicong;RAO Guiwei(College of Biology and Environmental Engineering,Zhejiang Shuren University,Hangzhou 310015)

机构地区：[1]浙江树人大学生物与环境工程学院,杭州310015

出　　处：《分析试验室》2020年第3期293-297,共5页Chinese Journal of Analysis Laboratory

基　　金：浙江省科技厅分析测试项目(LGC19B050010);浙江树人大学实验室开放项目(2019JS1003)资助。

摘　　要：建立了深共熔溶剂-高效液相色谱联用提取测定环境水样中3种药品和个人护理品(PPCPs)的方法。通过优化前处理条件,3种PPCPs(氯霉素、氯苯甘醚和萘普生)利用氯化胆碱-乙二醇深共熔溶剂为提取剂,经超声功率120 W下超声波提取5 min,离心转速9000 r/min下离心10 min富集提取。采用外标法定量分析,在5.0~200.0 mg/L范围内线性关系良好,相关系数r≥0.9998。3种环境水样中PPCPs的回收率为81.4%~94.8%,相对标准偏差分别为1.5%,0.4%和0.3%。氯霉素、氯苯甘醚和萘普生的方法检出限(LODs)分别为0.9,3.3,1.6 mg/L,定量限(LOQs)分别为3.1,12.2,5.0 mg/L。方法能够满足环境水样中3种PPCPs的检测需求。A method for the determination of three pharmaceutical and personal care products(PPCPs)in water samples was developed by deep eutectic solvents coupled with high performance liquid chromatography(HPLC).Through the optimization of pretreatment conditions,three PPCPs(chloramphenicol,chlorphenesin and naproxen)were extracted from choline chloride-ethylene glycol.The samples were extracted with ultrasonic power of 120 W for 5 min and centrifuged at speed of 9000 r/min for 10 min.The method showed good linear relationship in the range of 5.0-200.0 mg/mL of the three PPCPs with a correlation coefficient of r≥0.9998.The limits of detection(LODs)were 0.9,3.3 and 1.6 mg/L,and limits of quantification(LOQs)were 3.1,12.2 and 5.0 mg/L,respectively.The average recoveries of PPCPs were 81.4%-94.8% and relative standard deviations(RSDs)were 1.5%,0.4% and 0.3%,respectively.The method was suitable for the determination of three PPCPs in water samples.

关 键 词：深共熔溶剂 高效液相色谱 环境水样 药品与个人护理品 

分 类 号：O658[理学—分析化学]