射血分数保留的心力衰竭患者MMP-2、MMP-9、Gal-3的浓度变化及其临床意义  

Changes of MMP-2,MMP-9 and Gal-3 in heart failure patients with preserved ejection fraction and their clinical significance

作　　者：徐洁[1] 郭衍楷 曹桂秋[1] 王贵鹏[1] 薄雅坤 张鹏珂 周莉莉 Xu Jie;Guo Yankai;Cao Guiqiu;Wang Guipeng;Bo Yakun;Zhang Pengke;Zhou Lili(Department of Cardiology, the Fifth Affiliated Hospital of Xin Jiang Medical University, Urumqi 830011, China)

机构地区：[1]新疆医科大学第五附属医院心血管内科,830011 [2]新疆医科大学第五附属医院超声科,830011

出　　处：《疑难病杂志》2020年第5期438-442,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：新疆维吾尔自治区自然科学基金资助项目(2016D01C244)。

摘　　要：目的观察射血分数保留的心力衰竭(HF-PEF)患者血清中基质金属蛋白酶-2(MMP-2)、MMP-9及半乳糖凝集素-3(Gal-3)的浓度变化及其临床意义。方法选取2016年7月—2017年6月新疆医科大学第五附属医院心血管内科诊治的HF-PEF患者88例作为HF-PEF组,非心力衰竭患者35例为NHF组,均采用ELISA法测定血清MMP-2、MMP-9及Gal-3的浓度,超声测定左房直径(LA)、左室舒张末期内径(LVEDD)及左室射血分数(LVEF),并分析其相关性。结果HF-PEF组患者血清MMP-2、MMP-9及Gal-3浓度明显高于NHF组(t/P=12.952/0.000、17.618/0.000、14.801/0.000),并随着心功能分级升高而显著增加(F/P=78.72/0.000、127.531/0.000、86.418/0.000);HF-PEF组LAD水平大于NHF组,LVEF水平低于NHF组(P均<0.01),而2组LVEDD水平比较差异无统计学意义(P>0.05)。血清MMP-2、MMP-9和Gal-3浓度与LAD、LVEDD呈正相关(LAD:r/P=0.716/0.000、0.712/0.000、0.661/0.000;LVEDD:r/P=0.267/0.012、0.325/0.002、0.280/0.008),与LVEF呈负相关(r/P=-0.357/0.001、-0.547/0.000、-0.451/0.000)。结论检测血清中MMP-2、MMP-9及Gal-3浓度有助于HF-PEF患者病情早期诊断及其疾病严重程度的判断。Objective To observe the changes of serum matrix metalloproteinase-2(MMP-2),MMP-9 and galactose agglutinin-3(Gal-3)in patients with heart failure(HF-PEF)with preserved ejection fraction and its clinical significance.Methods From July 2016 to June 2017,88 HF-PEF patients were selected as HF-PEF group and 35 non heart failure patients as NHF group The concentrations of MMP-2,MMP-9 and Gal-3 in serum were measured by ELISA,the left atrial diameter(LA),left ventricular end diastolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)were measured by ultrasound,and the correlation was analyzed.Results The concentrations of MMP-2,MMP-9 and Gal-3 in HF-PEF group were significantly higher than those in NHF group(t/P=12.952/0.000,17.618/0.000,14.801/0.000),and increased with the increase of cardiac function grade(F/P=78.72/0.000,127.531/0.000,86.418/0.000).The LA level of HF-PEF group was higher than that of NHF group,while the LVEF level of HF-PEF group was lower than that of NHF group(P<0.01).The concentrations of MMP-2,MMP-9 and Gal-3 were positively correlated with La and LVEDD(LAD:r/P=0.716/0.000,0.712/0.000,0.661/0.000;LVEDD:r/P=0.267/0.012,0.325/0.002,0.280/0.008),and negatively correlated with LVEF(r/P=-0.357/0.001,-0.547/0.000,-0.451/0.000).Conclusion The detection of MMP-2,MMP-9 and Gal-3 in serum is helpful for the early diagnosis of HF-PEF and the judgment of disease severity.

关 键 词：射血分数保留的心力衰竭 基质金属蛋白酶-2 基质金属蛋白酶-9 半乳糖凝集素-3 

分 类 号：R54[医药卫生—心血管疾病]