口腔贴膜剂的配方优化及黏附性能测试  

Formulation Optimization and Adhesion Performance Test of Oral Film

作　　者：陈邈 孔祥烨 李黎仙 高鹰 Chen Miao;Kong Xiangye;Li Lixian;Gao Ying(Technology Research Center,Health Product Division,Yunnan Baiyao Group Co.,Ltd.,Kunming 650217,China)

机构地区：[1]云南白药集团股份有限公司健康品事业部技术研发中心,云南昆明650217

出　　处：《广东化工》2020年第7期82-84,共3页Guangdong Chemical Industry

摘　　要：采用响应面优化法对口腔贴膜剂配方及黏附性能进行优化,考察了不同配方比例的聚乙烯醇17-88、羧甲基纤维素钠、甘油对终产品加权评分的影响,加权评分项包括贴膜剂外观、体外黏附力、溶解时间。研究发现,聚乙烯醇17-88和羧甲基纤维素钠对贴膜剂终产品加权评分有显著性影响。模型预测值与实测值之间无显著性差异,说明模型预测性良好。Response surface method was applied to optimize the formulation and adhesion performance of oral film.The influence of different recipe proportion of PVA17-88,CMC-Na and glycerin on weighted score of final products were evaluated.The weighted score included appearance evaluation,in vitro adhesive force and dissolution time.The results showed that both PVA17-88 and CMC-Na had significant effects on the response value.There were no significant differences between predicted value and measured value.This model had satisfactory predictability.

关 键 词：贴膜剂 黏附性 聚乙烯醇 羧甲基纤维素钠 

分 类 号：TQ[化学工程]