米力农对重症心衰患者血清炎症因子及心功能的影响  

Curative effect of milrinone on biomarkers of inflammatory and cardiac function in patients with severe chronic heart failure

作　　者：罗娟 LUO Juan(The Second Hospital of WISCO,Hubei Wuhan 430085,China)

机构地区：[1]武汉钢铁(集团)公司第二职工医院重症医学科,湖北武汉430085

出　　处：《临床医药文献电子杂志》2020年第17期5-7,共3页Electronic Journal of Clinical Medical Literature

摘　　要：目的本研究旨在探讨米力农对慢性重症心力衰竭患者的治疗作用及其对体内炎症因子的影响。方法40例慢性重症心力衰竭、心输出量减低患者作为研究对象,随机分为观察组和对照组,每组20例。比较用药前及用药48小时后,两组患者心功能、血清血浆肌钙蛋白、NT-pro-BNP、白介素-6、肿瘤坏死因子α等指标的变化情况。结果药物治疗后观察组患者心功能好转明显,同时血清白细胞介素-6、肿瘤坏死因子α、NTpro-BNP均有显著改善(P<0.05);而肌钙蛋白水平无显著增加(P>0.05)。结论慢性重症心衰患者中,持续性心肌损伤常见;米力农在纠正心衰,改善炎症反应方面发挥重要作用,而且不会加重心肌损伤。Objective The purpose of this study was to investigate the effects of milrinone on biomarkers of inflammatory and cardiac function in patients with severe chronic heart failure.Methods 40 Patients with chronic severe heart failure and cardiac output reduction were enrolled in this study.Patients were divided into two groups randomly,20 patients in each group.Blood samples were taken just before and after 48 hours of treatment.The changes of inflammatory cytokines,such as troponin,N-terminal-pro-BNP,interleukin-6,tumor necrosis factorα,and cardiac function were compared before and after 48 hours of drug infusion.Results The cardiac function after drug administration were improved,while serum interleukin-6,tumor necrosis factor-a and N-terminal-pro-BNP were also significantly improved(P<0.05),while the level of troponin did not increase significantly(P=0.35).Conclusion Persistent myocardial injury is common in patients with chronic severe heart failure,and initiation of milrinone did not result in exacerbation of myocardial injury but instead was associated with salutary effects on inflammatory biomarkers.

关 键 词：米力农 慢性重症心衰 炎症因子 心肌损伤 

分 类 号：R541.61[医药卫生—心血管疾病]