雌-孕激素序贯治疗对药物流产后出血患者卵巢功能的影响研究  

The Effect of Sequential Treatment of Estrogen and Progesterone on Ovarian Function in Patients with Bleeding after Drug Abortion

作　　者：陈秀平 朱春霞 杨霞 刘佛秀 钟惠群 CHEN Xiu-ping;ZHU Chun-xia;YANG Xia;LIU Fu-xiu;ZHONG Hui-qun(Xingguo County Maternal and Child Health Hospital,Ganzhou Jiangxi 342400,China)

机构地区：[1]江西省兴国县妇幼保健院,江西赣州342400

出　　处：《药品评价》2020年第2期32-33,共2页Drug Evaluation

基　　金：赣州市指导性科技计划项目(GZ2019ZSF483)。

摘　　要：目的:探讨雌-孕激素序贯治疗对药物流产后出血患者卵巢功能的影响。方法:选取2018年4月至2019年10月60例药物流产后异常出血患者,按照研究方法的不同分为两组,对照组(n=30)采用常规止血治疗,观察组在对照组基础上实施雌-孕激素序贯治疗,观察阴道出血量、阴道出血时间、月经恢复时间、首次经期时间、流产后7d血清雌激素(E2)、孕酮(P)水平、血管生成调节因子(Ang-1、Ang-2)。结果:治疗后,观察组出血少于月经量比例高于对照组,P<0.05;观察组患者月经恢复时间、首次月经时间、阴道出血时间均短于对照组,P<0.05;治疗后,观察组E2高于对照组,P低于对照组,P<0.05;治疗后,观察组子宫内膜组织的Ang-1、Ang-2均低于对照组,P<0.05。结论:雌-孕激素序贯治疗对药物流产后出血患者具有明显效果,可改善卵巢功能,促进患者康复,可推广使用。Objective:To explore the effect of sequential treatment of estrogen and progesterone on ovarian function in patients with bleeding after drug abortion.Methods:60 patients with abnormal bleeding after drug abortion from April 2018 to October 2019 were divided into two groups according to different research methods.The control group(n=30)was treated with routine hemostasis.The observation group was treated with Estrogen Progesterone sequential therapy on the basis of the control group.The amount of vaginal bleeding,the time of vaginal bleeding,the time of menstrual recovery,the time of the first menstrual period and the serum estrogen(E),progesterone(P)level,angiogenic regulators(Ang-1,Ang-2)7 days after abortion were observed.Results:After treatment,the proportion of bleeding less than menstrual volume in the observation group was higher than that in the control group(P<0.05);the time of menstrual recovery,first menstrual period and vaginal bleeding in the observation group were shorter than that in the control group(P<0.05);after treatment,E2 in the observation group was higher than that in the control group(P<0.05);after treatment,Ang-1 and Ang-2 in the endometrial tissue in the observation group were lower than that in the control group(P<0.05).Conclusion:The sequential treatment of estradiol and progesterone has obvious effect on the patients with bleeding after drug abortion.It can improve the ovarian function,promote the recovery of patients,and can be widely used.

关 键 词：药物流产 阴道出血 雌-孕激素序贯 卵巢功能 血管生成调节因子 

分 类 号：R714.461[医药卫生—妇产科学]