黄苍湿疹喷雾薄膜剂处方优化  

Optimization of prescription for Huang Cang eczema spray film agent

作　　者：王晓瑜 张磊 郭一沙 李慧敏 王振国 张莉[2] WANG Xiaoyu;ZHANG Lei;GUO Yi-sha;LI Hui-min;WANG Zhen-guo;ZHANG Li(Characteristic Medical Center of the Chinese People's Armed Police Force,Tianjin 300162,China;Logistics College of the Chinese People's Armed Police Force,Tianjin 300162,China)

机构地区：[1]武警特色医学中心,天津300162 [2]武警后勤学院,天津300162

出　　处：《实用药物与临床》2020年第5期454-456,共3页Practical Pharmacy and Clinical Remedies

基　　金：天津市科技计划项目(15ZXLCSY00040)。

摘　　要：目的选用正交设计法对黄苍湿疹喷雾薄膜剂的处方进行筛选,得出最优处方组成。方法按正交设计L9(34)表安排实验,选择聚乙烯比咯烷酮(PVP-30)浓度(%)、壳聚糖浓度(%)、羟丙甲基纤维素(HPMC)浓度(%)、乙醇浓度(%)为因素,每个因素选取3个水平,以喷射效果、成膜质地、流动性、紧绷感与成膜时间为指标对黄苍湿疹喷雾薄膜剂的处方进行筛选。结果喷雾薄膜剂的最优处方为PVP-30浓度6.0%、壳聚糖浓度0.2%、HPMC浓度1.0%、乙醇浓度45%。结论按优化处方制备的喷雾薄膜剂溶液澄清透明,喷射时呈雾状,成膜性良好。Objective To screen the formulation of Huang Cang eczema spray film agent by orthogonal design and get the best prescription.Methods According to the orthogonal design L9(34) table experiments were arranged,the concentrations of polyvinylpyrrolidone(PVP-30)(%),chitosan(%),hypromellose(HPMC)(%),and alcohol(%) were selected as the factors,and three levels were selected for each factor,and the prescription of Huang Cang eczema spray film agent was screened with spray effect,film traits,liquidity,tension and film forming time as the indicators.Results Optimal prescription of the spray film agent was as follows:PVP-30 concentration was 6.0%,chitosan concentration was 0.2%,HPMC concentration was 1%,and alcohol concentration was 45%.Conclusion The spray film solution prepared by the optimized prescription is clear and transparent,and the spray is foggy and good in film formation.

关 键 词：薄膜剂 聚乙烯比咯烷酮 壳聚糖 羟丙甲基纤维素 正交设计 

分 类 号：R943[医药卫生—药剂学]