桂枝茯苓组方的网络药理学研究  

Network Pharmacology Study of Chinese Medicine Guizhifuling Formulae

作　　者：杨书彬[1] 裴晨晨 师伟[3] 王信[3] 李娜[4] 曹广尚[3] 张海鸣[2] 聂颖兰[2] 孙健[2] YANG Shubin;PEI Chenchen;SHI Wei;WANG Xin;LI Na;CAO Guangshang;ZHANG Haiming;NIE Yinglan;SUN Jian(Heilongjiang University Of Chinese Medicine,Harbin Heilongjiang 150040,China;State Key Laboratory Breeding Base of Dao-di Herbs,Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan Shandong 250355,China;Shandong University of Traditional Chinese Medicine,Jinan Shandong 250355,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]中国中医科学院医学实验中心,道地药材国家重点实验室培育基地,北京100700 [3]山东中医药大学附属医院,山东济南250011 [4]山东中医药大学,山东济南250355

出　　处：《中国药物警戒》2020年第4期214-220,共7页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(81102672);中央级公益性科研院所基本科研业务费专项资金(ZZ2019003);中央级公益性科研院所基本科研业务费专项资金(ZZ2015016);国家重点实验室培育项目(P TSJ2018002)。

摘　　要：目的基于网络药理学研究桂枝茯苓组方治疗疾病的主要活性成分及潜在靶点。方法从BATMAN-TCM数据库提取桂枝、茯苓、牡丹皮、白芍、桃仁的化学成分,以Score≥48和P≤0.05筛选活性成分及作用靶点,分析靶点富集的信号通路与疾病,构建药材-成分-靶点-通路网络,分析桂枝茯苓组方治疗疾病的药理作用机制。结果获得虫草素、苯乙烯、茯苓酸、肉桂醛、肉桂酸等活性成分以及ADORA1、ADORA2A、HTR1B、CHRM2、CHRM4等核心靶点。主要治疗神经系统、心血管系统、生殖系统等三类疾病,包括疼痛、偏头痛、高血压、心脏衰竭、心率失常、前列腺增生症、勃起功能障碍、子宫内膜癌、子宫内膜异位症等,另外发现该组方具有治疗抑郁症、精神分裂、酒精依赖、阿尔茨海默病、药物依赖等疾病的潜在疗效。结论通过网络药理学方法研究桂枝茯苓组方的多成分、多靶点药理学机制,为该组方的临床应用和开发提供新的思路。Objective To study the main active ingredients and potential targets of Guizhifuling formulae for treatment diseases based on network pharmacology. Methods The chemical constituents of ramulus cinnamom poria, tree peony bark, radix paeoniae alba and peach seed were extracted from the BATMANTCM database. The active ingredients and target targets were screened with scores ≥ 48 and P ≤ 0.05, and the signal pathways and diseases of target enrichment were analyzed to establish a medicinal materialtarget-pathway network and analyze the pharmacological action mechanism of Guizhifuling formulae for treating diseases. Results Core targets such as ADORA1, ADORA2 A, HTR1 B, CHRM2, CHRM4 and other active ingredients such as Cordycepin, Styrene, Pachymic acid, Cinnamaldehyde, trans-Cinnamic acid were obtained. Mainly treats three types of diseases including nervous system, cardiovascular system and reproductive system, including pain, migraine, hypertension, heart failure, arrhythmia, benign prostatic hyperplasia, erectile dysfunction, endometrial cancer, endometriosis et al. In addition, this formulae was found to have potential therapeutic effects in the treatment of depression, schizophrenia, alcohol dependence, Alzheimer’s disease and drug dependence. Conclusion Studying multi-component, multi-target pharmacological mechanism of Guizhifuling formulae through the network pharmacology method provides new ideas for clinical application and development of this prescriptions.

关 键 词：桂枝茯苓组方 网络药理学 BAT-MAN TCM数据库 药理机制 

分 类 号：R285.5[医药卫生—中药学]