细胞钙转运系统研究进展  

Advances in Cellular Calcium Transport System

作　　者：刘怡静 柏蓉 鲍丽琴 孙鲁宁 张学会 龚晓健[1] 王永庆 LIU Yijing;BAI Rong;BAO Liqin;SUN Luning;ZHANG Xuehui;GONG Xiaojian;WANG Yongqing(Department of Pharmacology,China Pharmaceutical University,Nanjing 210009;Research Division of Clinical Pharmacology,the First Affiliated Hospital with Nanjing Medical University,Nanjing 210029;Jiangsu Shengze Hospital,Suzhou 215228,China)

机构地区：[1]中国药科大学药理学教研室,南京210009 [2]南京医科大学第一附属医院临床药理研究室,南京210029 [3]江苏盛泽医院药学部,苏州215228

出　　处：《药学与临床研究》2020年第2期125-130,共6页Pharmaceutical and Clinical Research

基　　金：江苏省药学会奥赛康医院药学基金(A201615);苏州市产业技术创新专项(SYSD2016046);苏州市“科教兴卫”青年科技项目(KJXW2016067)。

摘　　要：钙离子是重要的细胞信号分子。胞内和胞外、胞浆和细胞器之间的Ca2+转运都依赖于钙转运系统的精确调控。钙转运系统包括钙泵、钙通道、Na^+/Ca^2+交换体及膜结构域,如质膜的PMCA、NCX、VGCC、LGCC和TRP通道;内质网膜的SERCA、IP3Rs和RyRs等;线粒体的MCU和NCLX;内溶酶体的TPCs;联结质膜和内质网膜的CRAC通路;联结内质网膜和线粒体膜的MAM结构域等。本文对定位于质膜、内质网和线粒体的钙转运系统的种类、功能、组织分布、相关疾病以及抑制剂作综述。Calcium ion is a vital cell signaling molecule,which acts as a double-edged sword to regulate both life and death of cells.The precise control of calcium ion transport includes the uptake and excretion of cytosolic Ca2+and the transport of Ca^2+ among endoplasmic/sarcoplasmic reticulum,mitochondrion and other organelles.There are many types of calcium ion transport systems and each of them is unique.There are PMCA,NCX,VGCC,LGCC,and TRP channels on plasma membrane;SERCA,IP3Rs,and RyRs on endoplasmic reticulum;MCU and NCLX on mitochondrion;and TPCs on endolysosome.Furthermore,CRAC can connect the cytomembrane to the ER membrane.And Ca^2+ released from ER can be ingested into mitochondrion via MAM microdomain.In this article,the types,structures,fuctions,distribution,related diseases and inhibitors of calcium ion transport systems are reviewed.

关 键 词：钙泵 钙通道 Na^+/C^a2+交换体 钙调控 

分 类 号：R963[医药卫生—微生物与生化药学]