白藜芦醇滴丸的制备工艺与质量标准研究  

Preparation and Quality Standard Research of Resveratrol Dropping Pills

作　　者：王晴晴 王晓楠 余双双 李文 李昭瑩 蒋雄 杨善彬[1,2] 李霄 李标 蒲道俊 Wang Qingqing;Wang Xiaonan;Yu Shuangshuang;Li Wen;Li Zhaoying;Jiang Xiong;Yang Shanbin;Li Xiao;Li Biao;Pu Daojun(College of Chemistry,Chongqing Normal University,Chongqing 401331;Engineering Research Center for Biotechnology of Active Substances,Ministry of Education,Chongqing Normal University,Chongqing 401331;Southwest Pharmaceutical Co.,Ltd.,Chongqing 400038,China)

机构地区：[1]重庆师范大学化学学院,重庆401331 [2]重庆师范大学活性物质生物技术教育部工程研究中心,重庆401331 [3]西南药业股份有限公司,重庆400038

出　　处：《广东化工》2020年第8期16-18,共3页Guangdong Chemical Industry

基　　金：重庆市高校创新团队项目(CXTDX201601018);活性物质生物技术教育部工程研究中心开放基金项目(No.20150408,AS201903);重庆师范大学成果转化项目基金(15XZH08);重庆师范大学博士启动项目(12XLB006);重庆市大学生创新创业训练计划项目(S201910637014);重庆市社会事业与民生保障科技创新专项项目(cstc2015shmszx80060)。

摘　　要：在单因素实验的基础上设计正交试验,优化白藜芦醇滴丸的最佳制备工艺为:复合基质PEG4000︰PEG6000为1︰1,药物︰复合基质为1︰8,药液温度为90℃,滴速为50 d/min。从滴丸外观、丸重差异、滴丸粒径、溶出时限和白藜芦醇在滴丸中的含量等几个方面进行质量标准研究,由最佳制备工艺制备的滴丸符合中国药典对滴丸剂的相关要求。The orthogonal experiment was designed on the basis of single factor experiment,and the best craft for the preparation of dripping pills was selected.The quality standards were studied from the appearance of dripping pills,weight difference,the particle size of dripping pills,dissolution time and content of the resveratrol in dropping pills.The orthogonal experiment results showed that the best craft for the preparation of dropping pills was as follows:the ratio of the composite matrix PEG4000 and PEG6000 was 1︰1,the ratio of the drug to the composite matrix was 1︰8,the liquid temperature was 90℃,and the dripping rate was 50 drop/min.After studying the quality standard of resveratrol dropping pills which was prepared by the optimized conditions,the relevant requirements of Chinese Pharmacopoeia for dripping pills was matched.

关 键 词：白藜芦醇 滴丸 单因素试验 正交试验 质量标准研究 

分 类 号：R283.6[医药卫生—中药学]