注射STZ方式对制备糖尿病肾病模型的影响研究  

Study on the Effects of Injection of STZ on Diabetic Nephropathy Model

作　　者：修贤杰 张萍[1] 郑小鹏 朱思源 陈光 Xiu Xianjie;Zhang Ping;Zheng Xiaopeng;Zhu Siyuan;Chen Guang(Department of Clinical Medicine,Jiamusi University,Jiamusi 154000;The First Affiliated Hospital of Jiamusi University,Jiamusi 154000;Taizhou University Medical College,Taizhou 318000,China)

机构地区：[1]佳木斯大学医学部临床医学院,黑龙江佳木斯154000 [2]佳木斯大学附属第一医院,黑龙江佳木斯154000 [3]台州学院医学院,浙江台州318000

出　　处：《广东化工》2020年第8期59-60,共2页Guangdong Chemical Industry

基　　金：黑龙江省大学生创新项目,编号:201710222028;佳木斯大学交叉学科项目,编号:12J201503。

摘　　要：糖尿病肾病(diabetic nephropathy,DN)是糖尿病(diabetes mellitus,DM)晚期微血管并发症之一,是DM患者死亡的重要原因。DN的致病机制和发病过程与其他糖尿病微血管并发症一样未完全阐明,可以肯定的是高血糖是导致DN发病的关键因素。目前使用的DN动物模型多是在糖尿病模型建立的基础上建立的。随着病程的发展,建立的DM模型会逐渐发展为合适的DN模型,建立合适的DN模型是研究DN发病机理的基础。如今建立DM模型最常用的方法是注射STZ进行造模。本文从实验动物选择,饲料种类,STZ剂量,造模方法,成模标准几个方面上进行概述。Diabetic nephropathy(DN)is one of the late microvascular complications of diabetes mellitus(DM)and is an important cause of death in patients with DM.The pathogenesis and pathogenesis of DN,like other diabetic microvascular complications,are not fully elucidated.Hyperglycemia is certainly the key factor that causes DN.Most of the DN animal models currently used are based on the establishment of diabetes models.With the development of the disease course,the established DM model will gradually develop into a suitable DN model.The establishment of a suitable DN model is the basis for studying the pathogenesis of DN.The most common way to build DM models today is to inject STZ for modeling.This article summarizes the selections of experimental animals,feed types,STZ dosages,modeling methods,and modeling standards.

关 键 词：糖尿病肾病(DN) 动物模型 链脲佐菌素(STZ) 

分 类 号：TQ[化学工程]