衍生气相色谱法测定草酸艾司西酞普兰中甲磺酸烷基酯类  

GC-FID-derivative Technique Determination of Methanesulfonic Acid Alkyl Ester in Escitalopram Oxalate

作　　者：侯奇伟 梁伟 杜建 Hou Qiwei;Hou Liangwei;Du Jian(Hu’nan Dongting Pharmaceutical Co.,Ltd.,Changde 415000,China)

机构地区：[1]湖南洞庭药业股份有限公司,湖南常德415000

出　　处：《广东化工》2020年第8期174-175,共2页Guangdong Chemical Industry

摘　　要：目的:建立衍生气相色谱法同时检测草酸艾司西酞普兰中甲磺酸甲酯、甲磺酸乙酯、甲磺酸异丙酯三种甲磺酸烷基酯。方法:采用NaI-H2O碘化衍生,利用DB-WAX毛细管柱(30m*0.45 mm,0.85 um)分离,氢火焰离子化(FID)检测器。结果:碘甲烷线性范围为0.2784~10.44μg/mL,碘乙烷线性范围为0.2944~11.04μg/mL,2-碘丙烷线性范围为0.2608~9.78μg/mL。该方法专属性、准确度等指标均符合要求。结论:本方法可用于测定草酸艾司西酞普兰中的甲磺酸甲酯、甲磺酸乙酯、甲磺酸异丙酯三种甲磺酸烷基酯成分的同时碘化衍生分离分析,方法简便、结果可靠、重现性好。Objective To establish a derivative gas chromatography method simultaneously quantitative determination of methyl methanesulfonate(MMS),ethyl methanesulfonate(EMS),isopropyl methanesulfonate(IMS)in escitalopram oxalate.ethods:NaI-H2O solution as the iodonation agent,DB-WAX(30m*0.45 mm,85 um)capillary column was used to separate the fatty acids and FID for quantitative determination.esults:The linear range of Methyl iodide is 0.2784~10.44μg/mL the linear range of Iodoethane is 0.2944~11.04μg/mL the linear range of 2-iodopropane is 0.2608~9.78μg/mL.The method's specificity and accuracy meet the requirements.Conclusion:The method shows satisfactory repeatability,simplicity and convenience,and is valid in simultaneous derivation separation and analysis of these methanesulfonic acid alkyl ester in escitalopram oxalate.

关 键 词：草酸艾司西酞普兰 衍生化 气相色谱法 甲磺酸甲酯 甲磺酸乙酯 甲磺酸异丙酯 

分 类 号：O65[理学—分析化学]