Preparation,Characterization and Antioxidant Activity of Inclusion Complex of Bakuchiol with Hydroxypropyl-β-cyclodextrin  

作　　者：DENG Yunxia LIU Minyan WANG Lu BIAN Yonggang SHAO Zhiyu 邓云霞;刘敏燕;王露;卞永刚;邵志宇(College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China)

机构地区：[1]College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China

出　　处：《Journal of Donghua University(English Edition)》2020年第1期35-42,共8页东华大学学报（英文版）

基　　金：Fundamental Research Funds for the Central Universities(No.2232018D3-40);National Natural Science Foundation of China(No.81671508)。

摘　　要：Bakuchiol isolated from Psoralea corylifolia is a naturally occurring prenylated phenolic monoterpene with a variety of bioactivities.The aim of this study was to improve the water solubility and thermal stability of bakuchiol through complexing it with hydroxypropyl-β-cyclodextrin(HP-β-CD).The bakuchiol/HP-β-CD inclusion complex's behavior and characterization were investigated by ultraviolet-visible(UV-vis)spectroscopy,Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),X-ray diffraction(XRD),1H nuclear magnetic resonance(NMR),and two-dimensional(2D)NMR.The obtained results indicated the formation of 1∶1 inclusion complex for bakuchiol with HP-β-CD.Water solubility of bakuchiol was significantly improved by complexation with HP-β-CD as demonstrated by phase solubility studies.The encapsulation of bakuchiol was confirmed by UV-vis,FT-IR,and XRD.The thermal stability was effectively enhanced by TGA and derivative thermogravimetry(DTG)analysis.In vitro antioxidant activity showed that bakuchiol/HP-β-CD inclusion complex had a little higher antioxidant ability than free bakuchiol.Moreover,we got the possible inclusion mode for the bakuchiol/HP-β-CD inclusion complex through NMR analysis.These results suggest that the inclusion complex can be a potentially useful approach in the design of novel formulations of bakuchiol for medical applications.

关 键 词：BAKUCHIOL hydroxypropyl-β-cyclodextrin(HP-β-CD) nclusion COMPLEX CHARACTERIZATION 

分 类 号：O629.9[理学—有机化学] R944.9[理学—化学]