益肾通络解毒汤对气阴两虚兼毒瘀互结型糖尿病肾病疗效及氧化应激的影响  

Effect of Yishen Tongluo Jiedu Decoction on Clinical Efficacy and Oxidative Stress of Qi and Yin Deficiency and Toxic and Malignant Diabetic Nephropathy

作　　者：朱静 ZHU Jing(Shenyang Municipal Hospital of Traditional Chinese Medicine,Shenyang 110003,Liaoning,China)

机构地区：[1]沈阳市中医院药剂科,辽宁沈阳110003

出　　处：《实用中医内科杂志》2020年第2期39-42,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：辽宁省博士启动基金(20170520316)。

摘　　要：目的探讨益肾通络解毒汤对气阴两虚兼毒瘀互结型糖尿病肾病的临床疗效及对氧化应激的影响。方法选取2018年1月—2019年6月医院收治的120例气阴两虚兼毒瘀互结型糖尿病肾病患者,随后依据患者就诊顺序将其分为观察组及对照组各60例,两组均予以口服降糖药、皮注胰岛素、运动疗法、饮食控制等基础治疗,在基础治疗上对照组加以尿毒清颗粒治疗,观察组予以益肾通络解毒汤治疗,比较治疗前后两组肾脏功能指标[肾小球滤过率(eGFR)、血肌酐(SCr)、24 h尿蛋白排泄率(24 h UAER)]、炎症指标[白细胞介素-6(IL-6)、超敏C反应蛋白(hsCRP)]、氧化应激指标[8-羟基脱氧鸟嘌呤(8-OHdG)、晚期糖基化终产物(AGEs)、丙二醛(MDA)、活性氧(ROS)、超氧化物歧化酶(SOD)、晚期氧化蛋白产物(AOPP)]变化情况,并比较两组病人的临床疗效。结果两组治疗疗程结束后,观察组肾功能、炎症反应及氧化应激水平各项指标均明显优于对照组(P<0.05)。观察组总有效率为90.00%,对照组总有效率为70.00%,观察组优于对照组(P<0.05)。结论益肾通络解毒汤治疗气阴两虚兼毒瘀互结型糖尿病肾病患者疗效确切,能有效改善患者的肾功能,其机制可能与其抑制炎症反应及抗氧化应激相关。Objective To investigate the clinical effect of Yishen Tongluo Jiedu Decoction on qi and yin deficiency and phlegm and blood stasis type diabetic nephropathy and its effect on oxidative stress.Methods A total of 120 patients with Qi and Yin deficiency and phlegm and blood stasis type diabetic nephropathy admitted to our hospital from January 2018 to June 2019 were enrolled.The patients were divided into observation group and control group according to the order of patients.The patients in both groups were treated with oral hypoglycemic agents,insulin injections,exercise therapy,diet control,etc.In the basic treatment,the patients in the control group were treated with urinary granules.The patients in the observation group were treated with Yishen Tongluo Jiedu Decoction.Renal function indexes in the two groups before and after[glomerular filtration rate(eGFR),serum creatinine(SCr),24-hour urinary protein excretion rate(24 h UAER)],inflammation index[interleukin-6(IL-6)),hypersensitive C-reactive protein(hsCRP),oxidative stress indicators[8-hydroxydeoxyguanine(8-OHdG),advanced glycation end products(AGEs),malondialdehyde(MDA),reactive oxygen species(ROS),changes in superoxide dismutase(SOD),advanced oxidation protein product(AOPP),and compare the clinical efficacy of the two groups of patients.Results After treatment at the end of the treatment,the renal function,inflammatory response and oxidative stress levels of the observation group were significantly better than the control group,both P<0.05.The total effective rate was 90.00%in the observation group and 70.00%in the control group.P<0.05.Conclusion Yishen Tongluo Jiedu Decoction is effective in treating patients with qi and yin deficiency and phlegm and blood stasis type diabetic nephropathy,and can effectively improve the renal function of patients.The mechanism may be related to its inhibition of inflammatory reaction and anti-oxidative stress.)

关 键 词：氧化应激 炎症反应 糖尿病肾病 益肾通络解毒汤 肾小球滤过率(eGFR) 血肌酐(SCr) 24 h尿蛋白排泄率(24h UAER) 白细胞介素-6(IL-6) 超敏C反应蛋白(hsCRP) 8-羟基脱氧鸟嘌呤(8-OHdG) 晚期糖基化终产物(AGEs) 丙二醛(MDA) 活性氧(ROS) 超氧化物歧化酶(SOD) 晚期氧化蛋白产物(AOPP) 

分 类 号：R587.1[医药卫生—内分泌]