701例健康妇女阴道微生态环境的状况分析及影响因素  

Evaluation of vaginal flora and its influence factors of 701 healthy women in China

作　　者：支秀霞 米兰[1] 刘朝晖[1,3] 张岱 ZHI Xiu-xia;MI Lan;LIU Chao-hui;ZHANG Dai(The First Hospital of Peking University,Beijing 100000,China;Beijing Miyun Maternal and Child Health Hospital,Beijing 101500,China;Beijing Obstetrics and Gynecology Hospital,Beijing 100000,China)

机构地区：[1]北京大学第一医院,北京100000 [2]北京市密云区妇幼保健院,北京101500 [3]北京市妇产医院,北京100000

出　　处：《临床医药文献电子杂志》2020年第10期15-17,共3页Electronic Journal of Clinical Medical Literature

摘　　要：目的了解健康女性阴道微生态情况及影响因素。方法选取健康体检妇女701例,采取阴道分泌物,进行阴道微生态评价,结合临床调查问卷分析影响阴道微生态的因素。结果健康女性中菌群正常者560例,占79.9%,异常菌群114例,占16.3%,包括菌群异常、菌群抑制、菌群增殖过度、BV中间型、BV和VVC。其中,BV中间型31例,占4.4%。BV阳性者20例,占2.9%。真菌菌丝阳性或芽生孢子阳性者37例,占5.3%。性生活频率与阴道菌群的密集度相关,相关系数为-0.116(P=0.003),性生活频率与微生态结果及菌群多样性无关(P>0.05)。比较采用不同避孕方式时阴道微生态结果差异有显著性,χ^2=16.788,(P=0.005),使用避孕套相较于宫内节育器阴道菌群正常的比例高,前者为86.9%,后者为72.3%,二者差异有显著性,χ^2=14.248,(P<0.001)。结论阴道微生态评价能够指导临床评价感染时及治疗后的阴道微生态状况。性生活频率与阴道菌群的密集度相关,但与微生态结果及菌群多样性无关。采用避孕套避孕相较于宫内节育器能够明显降低发生阴道菌群异常的几率。Objective To investigate the vaginal flora and its affecting factors in 701 healthy women.Methods During July 2008,701 cases of routine physical check-up in the gynecology outpatient department of Peking University First Hospital were enrolled.The vaginal secretions were examined for vaginal population's density,the diversity,the predominating population,and the inflammatory response.Factors influences vaginal flora investigated by questionnaires.Results Among 701 healthy women,normal vaginal flora was identified in 560(79.9%,560/701);abnormal flora was found in 114(16.3%,114/701),including abnormal Predominating Population,flora inhibited,flora over-proliferated,intermediate bacterial vaginosis(BV),BV and vulvavaginal candidasis(VVC).Among these,20 was BV(2.9%);37 was positive for fungi(5.3%).Frequency of sexual intercourse is associated with density of vaginal population(P=0.003).but not with diversity of vaginal flora(P>0.05).Vaginal flora has significant differences when various contraceptive methods were used,χ^2=16.788,(P=0.005).Compared with women using intrauterine device,women using condom have higher proportion of normal flora(72.3%VS86.9%),which is statistically significant,χ^2=14.248,(P<0.001).Conclusions The vaginal flora evaluation can assess the vaginal microenvironment.Comparing with condom use,women using intrauterine device has a higher risk of developing abnormal vaginal flora.

关 键 词：阴道微生态 阴道菌群 影响因素 

分 类 号：R711.3[医药卫生—妇产科学]