注射用益气复脉(冻干)联合多巴胺治疗小儿感染性休克的疗效观察  

Clinical observation of Yiqi Fumai(freeze-dried)combined with dopamine in the treatment of pediatric septic shock

作　　者：程钦 CHENG Qin(Department of Pediatrics,Guangzhou Medical University,Guangdong Guangzhou 510700,China)

机构地区：[1]广州医科大学第五附属医院儿科,广东广州510700

出　　处：《临床医药文献电子杂志》2020年第11期1-3,共3页Electronic Journal of Clinical Medical Literature

摘　　要：目的探讨注射用益气复脉(冻干)联合多巴胺治疗小儿感染性休克的临床疗效。方法选取2017年6月~2019年4月在我院诊治的小儿感染性休克患者118例,将患儿随机分为对照组和观察组,每组各59例。对照组给与多巴胺注射液治疗,5μg·kg^-1·min^-1,用5%葡萄糖注射液稀释后静脉滴注;观察组在此基础上联用益气复脉(冻干),1.2~5.22.5 g,用100 mL 5%葡萄糖注射液稀释后静脉滴注,1次/d。统计分析两组患儿治疗前后心率、每小时尿量、平均动脉压(MAP)、中心静脉压(CVP)和中心静脉血氧饱和度等指标变化情况、临床疗效和急性生理和慢性健康评分(APACHEⅡ)。结果治疗后,两组患儿心率降低,尿量、MAP、CVP和中心静脉血氧饱和度水平较治疗前升高;观察组患儿治疗后上述各项指标均较对照组改善明显;观察组的临床总有效率为94.9%较对照组的71.2%明显提高;观察组APACHEⅡ评分明显低于对照组,两组上述差异均具有统计学意义(P<0.05)。结论注射用益气复脉(冻干)联合多巴胺治疗小儿感染性休克临床疗效显著,可于较短时间内改善患儿组织氧代谢情况和微循环灌注,具有一定的临床借鉴意义。Objective To investigate the clinical efficacy of Yiqi Fumai(freeze-dried)combined with dopamine in the treatment of pediatric septic shock.Methods A total of 118 children with septic shock who were treated in our hospital from June 20 to April 2019 were enrolled.The children were randomly divided into the control group and the observation group,with 59 cases in each group.The control group was treated with dopamine injection,1μg kg^-1 min^-1,diluted with 5%glucose injection and intravenously instilled;the control group was combined with Yiqi Fumai(freeze-dried),1.2~5.22.5g,diluted with 250 mL of 5%dextrose injection,intravenous infusion,once/d.The clinically relevant indicators,clinical efficacy and acute physiological and chronic health scores(APACHE II)of the two groups were analyzed statistically.Results After treatment,the heart rate of the two groups decreased,urine volume,MAP,CVP and central venous oxygen saturation levels were higher than before treatment;the above indicators of the observation group were significantly improved compared with the control group;The total clinical effective rate was 94.9%,which was significantly higher than that of the control group.The APACHE II score in the observation group was significantly lower than that in the control group.The difference between the two groups was statistically significant(P<0.05).Conclusion The clinical efficacy of Yiqi Fumai(freeze-dried)combined with dopamine in the treatment of pediatric septic shock is significant,and it can improve the tissue oxygen metabolism and microcirculation perfusion in a short period of time.It has certain clinical significance.

关 键 词：多巴胺 益气复脉(冻干) 感染性休克 

分 类 号：R72[医药卫生—儿科]