MiR-let-7在细胞凋亡过程中作用的研究进展  

Research progress of miR-let-7 in cell apoptosis

作　　者：赵博欣 张志勇 黄立娟[1] Zhao Boxin;Zhang Zhiyong;Huang Lijuan(Department of Clinical Laboratory,the Second Affiliated Hospital,Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院检验科,150086

出　　处：《国际免疫学杂志》2020年第1期109-112,共4页International Journal of Immunology

摘　　要：细胞凋亡是一种由基因严格调控的、自发的、有序的细胞死亡方式,在参与生物体内组织胚胎发育、维持内环境稳态以及调节免疫系统和神经系统功能等方面具有重要作用.MiR-let-7(microRNA-let-7)是一类长度约为22个核苷酸的非编码RNA(non-coding RNAs,ncRNAs),其功能十分广泛,通过介导细胞增殖、分化和凋亡等细胞表型变化,参与体内诸多生理以及病理过程.越来越多的研究表明miR-let-7与细胞凋亡关系极为密切,因此阐明MiR-let-7在细胞凋亡过程中的调控作用,为进一步研究细胞凋亡的分子机制提供新的视角.Cell apoptosis is a autonomous and ordered death regulated tightly by gene.It’s important for embryonic development,maintaining tissue homeostasis,regulating immune system and development of nervous system.MiR-let-7(microRNA-let-7)is a kind of non coding RNAs(ncRNAs)with a length of about 22 nucleotides.It has a wide range of functions and participates in many physiological and pathological processes in vivo by mediating cell proliferation,differentiation,apoptosis and other phenotypic changes.More and more studies have shown that MiR-let-7 is closely related to apoptosis.Therefore,to clarify the regulatory role of MiR-let-7 in the process of apoptosis provides a new perspective for further study of the molecular mechanism of apoptosis.

关 键 词：MiR-let-7 细胞凋亡 

分 类 号：R3[医药卫生—基础医学]