Chen's Reagent: A Versatile Reagent for Trifluoromethylation,Difluoromethylenation, and Difluoroalkylation in Organic Synthesis  

作　　者：Qiqiang Xie Jinbo Hu 

机构地区：[1]Key Laboratory of Organofluorine Chemistry,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,345 Ling-Ling Road,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2020年第2期202-212,共11页中国化学（英文版）

基　　金：the National Basic Research Program of China(Nos.2015CB931900,2016YFB0101200);the National Natural Science Foundation of China(Nos.21632009,21421002);the Key Programs of the Chinese Academy of Sciences(No.KGZD-EWT08);the Key Research Program of Frontier Sciences of CAS(No.QYZDJ-SSW-SLH049);Shanghai Science and Technology Program(No.18JC1410601)is acknowledged。

摘　　要：Methyl fluorosulfonyldifluoroacetate(FSO2CF2CO2Me or MFSDA),often called"Chen's reagent",is commonly used to synthesize trifluoromethylated and difluoroalkylated compounds.This important reagent was initially developed as an efficient trifluoromethylating agent by Professor Qing-Yun Chen and co-workers at Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences in 1989.

关 键 词：compounds. REAGENT REAGENT 

分 类 号：O62[理学—有机化学]