Dehydrative Glycosylation Mediated by 2-Aryl-1,3-dithiane 1-Oxide via Sequential Activation of Sulfoxide and Sulfide  

作　　者：Xiang Zhao Lei Cai 

机构地区：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Huazhong University of Science and Technology,13 Hangkong Road,Wuhan,Hubei 430030,China

出　　处：《Chinese Journal of Chemistry》2020年第2期220-221,共2页中国化学（英文版）

摘　　要：Developing efficient glycosylation methods and strategies is always a top priority and endless pursuit for carbohydrate chemists to acquire complex glycosidic linkages.While most glycosylation reactions are step-wise,that is,installation of the leaving group at the anomeric position first followed by activation and coupling with acceptors(Scheme 1a),dehydrative glycosylation is obviously more straightforward.[1]In this strategy,C1-hemiacetals are directly activated to couple with acceptors,thus obviating additional C1 modification steps(Scheme 1b).Unfortunately,the intrinsic stability of C1-hemiacetals impedes their applications.

关 键 词：straight STEPS PURSUIT 

分 类 号：O62[理学—有机化学]