通腑醒神汤辅助神经内镜治疗高血压脑出血改善认知功能和凝血功能的价值  

Value of Tongfu Xingshen Decoction Assisted Neuroendoscopy in Treatment of Hypertensive Cerebral Hemorrhage to Improve Cognitive Function and Blood Coagulation Function of Patients

作　　者：李东峰 周国平[2] 周文科[3] 杨磊[2] 周详 LI Dongfeng;ZHOU Guoping;ZHOU Wenke;YANG Lei;ZHOU Xiang(Department of Brain Surgery,Sanya Hospital of Traditional Chinese Medicine,Sanya 572000,Hainan,China;Department of Neurosurgery,Nanvang Central Hospital,Nanyang 473100,Henan,China;Department of Neurosurgery,The First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453100,Henan,China)

机构地区：[1]三亚市中医院脑外科,海南三亚572000 [2]南阳市中心医院神经外科,河南南阳473100 [3]新乡医学院第一附属医院神经外科,河南新乡453100

出　　处：《中华中医药学刊》2020年第3期53-56,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81541030)。

摘　　要：目的通腑醒神汤辅助神经内镜治疗高血压脑出血改善患者认知功能和凝血功能的价值。方法选取2016年8月-2018年6月收治的80例高血压脑出血患者的临床资料进行分析,分为两组。对照组采用神经内镜治疗,观察组采用通腑醒神汤辅助神经内镜治疗,分析两组患者治疗后的临床疗效。结果两组患者治疗前中医证候评分组间比较,差异不具有统计学意义(P>0.05)。观察组患者治疗后半身不遂、偏身麻木、言语謇涩、口歪眼斜、头晕目眩评分低于对照组(P<0.05)。两组患者治疗前丙二醛(MDA)、内皮素(ET)、基质金属蛋白酶-9(MMP-9)、神经元特异性烯醇化酶(NSE)、凝血功能指标水平组间比较,差异不具有统计学意义(P>0.05)。观察组患者治疗后MDA、ET、MMP-9、NSE、纤维蛋白原(FIB)水平低于对照组,凝血酶原时间(PT)、活化部分凝血活酶时间(APPT)水平高于对照组(P<0.05)。两组患者治疗前简易精神状态量表(MMSE)、神经功能缺损量表(NIHSS)评分组间比较,差异不具有统计学意义(P>0.05)。观察组患者治疗后MMSE评分高于对照组,NIHSS评分低于对照组(P<0.05)。结论通腑醒神汤辅助神经内镜治疗高血压脑出血可有效减轻临床症状体征,可改善患者的凝血功能、神经功能及认知功能。Objective To analyze the value of Tongfu Xingshen Decoction assisted neuroendoscopy in the treatment of hypertensive cerebral hemorrhage to improve the cognitive function and blood coagulation function of patients. Methods The clinical data of 80 patients with hypertensive cerebral hemorrhage admitted to our hospital from August 2016 to June 2018 was analyzed, and the patients were divided into two groups. The control group was treated with neuroendoscopy and the observation group was treated with Tongfu Xingshen Decoction assisted neuroendoscopy and the clinical efficacy of the two groups was analyzed after treatment. Results Comparison of TCM syndrome evaluation between the two groups before treatment showed no statistical significance(P>0.05). After treatment, hemiplegia, hemiplegia, partial body numbness, astigmatic eyes and astigmatic dizziness scores of the observation group were lower than those of the control group(P<0.05). Before treatment,two groups’ malondialdehyde(MDA), endothelin(ET),matrix metalloproteinases-9(MMP-9),neuron specificity enolization enzyme(NSE) and blood coagulation function indexes between groups had no statistically significant difference(P>0.05). In the observation group after treatment,levels of MDA,ET,MMP-9,NSE and fibrinogen(FIB) were lower than those of the control group. The prothrombin time(PT) and activated partial coagulation time(APPT) were higher than those of the control group(P<0.05). Comparison of the two groups’ simple mental state scale(MMSE) and neurological impairment scale(NIHSS) before treatment showed no statistical significance(P>0.05). After treatment, the MMSE score of the observation group was higher than that of the control group, while the NIHSS score was lower than that of the control group(P<0.05). Conclusion Tongfu Xingshen Decoction assisted neuroendoscopy in the treatment of hypertensive intracerebral hemorrhage can effectively reduce the clinical symptoms and signs, and improve the coagulation function and neurological function and cognitive func

关 键 词：通腑醒神汤 神经内镜 高血压脑出血 认知功能 凝血功能 

分 类 号：R285.5[医药卫生—中药学]