连翘挥发油自微乳的制备及解热作用  

Preparation and Antipyretic Effect of Forsythia Volatile Oil Self-Microemulsifying Drug Delivery System

作　　者：郑立[1] 汤韵秋 余琳媛 刘美辰[1] 周忆梦 全云云 李芸霞[1] ZHENG Li;TANG Yunqiu;YU Linyuan;LIU Meichen;ZHOU Yimeng;QUAN Yunyun;LI Yunxia(School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Key Laboratory of Standardization for Chinese Herbal Medicine,Ministry of Education,National Key Laboratory Breeding Base of Systematic Research,Development and Utilization of Chinese MedicineResources,Chengdu 611137,Sichuan,China)

机构地区：[1]成都中医药大学药学院,四川省中药资源系统研究与开发利用重点实验室,省部共建国家重点实验室培育基地,四川成都611137

出　　处：《中华中医药学刊》2020年第3期149-153,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81573583);四川省科技厅省青年科技创新研究团队专项计划(2016TD0028,2017TD0001).

摘　　要：目的研究连翘挥发油自微乳处方组成和比例,并考察其解热药效。方法通过溶解性实验、因素考察和伪三相图绘制,以自乳化时间、乳化效果、乳滴粒径、多分散系数、稳定性为指标确定最佳处方;建立酵母致热大鼠模型,考察其和挥发油在体内解热药效。结果连翘挥发油自微乳的处方组成为连翘挥发油-油酸乙酯-吐温20-乙醇(25∶10∶81∶9),制得外观澄清透明的淡黄色油状液体,粒径为(37.41±0.014)nm,多分散系数0.211±0.018,电位(-7.05±0.53)mV,乳化时间32 s。解热药效结果显示,连翘挥发油自微乳能够有效抑制发热模型大鼠体温上升,降低模型大鼠体温。结论连翘挥发油自微乳制备简单,增加了药物在水中溶解度,有利于胃肠道吸收,提高了挥发油解热药效,为连翘挥发油新剂型的开发与利用奠定基础。Objective To study the composition and proportion of Forsythia suspense volatile oil for oral self-microemulsifying drugdelivery system and investigate its antipyretic effect. Methods The prescription and preparation technology were selected and optimized through the solubility experiment,factortestand pseudo-ternaryphase diagram method, using the self-emulsifying time, appearance, particle diameter, PDI and stability as selection indexes. We investigated its antipyretic efficacy in vivo by establishing a dry yeast-induced rat model.Result The prescription composition of Forsythia suspense volatile oil self microemulsion wasForsythia volatile oil-ethyloleate-Tween20-ethanol(25∶10∶40∶9). The acquired Forsythia suspense volatile oil self-microemulsion exhibited uniform and transparent, with the particle diameter(37.41±0.014)nm, polydispersity index 0.211±0.018, Zeta potential(-7.05±0.53) mV, self-emulsifying time 38 s. The result showed Forsythia suspense volatile oil self-microemulsion can effectively inhibit the temperature increase of rats with fever and decrease the temperature instead. Conclusion The preparation of Forsythia suspense volatile oil self-microemulsion is simple, increasing the solubility in water, making it better absorption in the stomach and intestine and enhancing the efficacy of antipyretic effect. It provides a basis for further development and utilization of Forsythia suspense volatile oil.

关 键 词：连翘 挥发油 自微乳 解热 

分 类 号：R283.1[医药卫生—中药学]