孕期孕酮、胎盘生长激素、糖链抗原125对高龄先兆流产患者妊娠结局的预测价值  

The predictive value of progesterone,GH and carbohydrate antigen 125 in early pregnancy for pregnancy outcome of older patients with threatened abortion

作　　者：孔双燕[1] 刘云 KONG Shuang-yan;LIU Yun(Gynecology Department,Zhoushan Hospital,Zhoushan,Zhejiang 316000,China;不详)

机构地区：[1]浙江省舟山医院妇科,浙江舟山316000 [2]浙江省舟山市妇幼保健院妇保科,浙江舟山316000

出　　处：《中国卫生检验杂志》2020年第7期833-836,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨孕期孕酮、胎盘生长激素、糖链抗原125对高龄先兆流产患者妊娠结局的预测价值。方法根据妊娠结局将135例高龄先兆流产患者分为保胎失败组46例和保胎成功组89例,并以60例高龄非先兆流产患者为对照组,测定血清孕酮、胎盘生长激素、糖链抗原125水平。结果3组孕12周和孕28周的血清孕酮、胎盘生长激素和糖链抗原125水平均不相同,保胎成功组血清孕酮与胎盘生长激素水平低于对照组,保胎失败组低于保胎成功组;保胎成功组糖链抗原125水平高于对照组,保胎失败组高于保胎成功组,差异有统计学意义(P<0.05)。ROC曲线分析结果显示,孕12周孕酮、胎盘生长激素、糖链抗原125的最佳工作点分别为24.8 ng/ml、17.5 ng/ml、30.6 kU/L,三者联合预测保胎失败的AUC为0.971;孕28周最佳工作点分别为74.5 ng/ml、28.6 ng/ml、56.6 kU/L,三者联合预测保胎失败的AUC为0.831。结论孕12周和28周孕酮、胎盘生长激素、糖链抗原125对高龄先兆流产患者妊娠结局均有较好的预测价值。Objective To explore the predictive value of progesterone,growth hormone(GH)and carbohydrate antigen 125 for pregnancy outcome of senile patients with threatened abortion.Methods According to pregnancy outcomes,135 patients with advanced threatened abortion were divided into abortion failure group(46 cases)and successful abortion group(89 cases),and 60 elderly patients with non-threatened abortion were used as the control group.All the subjects were conducted for the detection of hormone,placental growth hormone,and sugar chain antigen 125 levels.Results Serum progesterone,placental growth hormone,and sugar chain antigen 125 levels were different at 12 weeks and 28 weeks of gestation in the three groups.Serum progesterone and placental growth hormone levels in the successful pregnancy-preserving group were lower than those in the control group,and the failure pregnancy-preserving group was lower than the successful pregnancy-preserving group;the level of sugar chain antigen 125 in the successful pregnancy-preserving group was higher than that in the control group,and the failure-preserving group was higher than the successful pregnancy-preserving group;the difference was statistically significant(P<0.05).The results of ROC curve analysis showed that the optimal working points of progesterone,placental growth hormone,and sugar chain antigen 125 at 12 weeks gestation were 24.8 ng/ml,17.5 ng/ml,and 30.6 kU/L.The AUC of the combined prediction of fetal failure was 0.971.The optimal working points at the 28th week of pregnancy were 74.5 ng/ml,28.6 ng/ml,and 56.6 kU/L,respectively.The AUC of the combined prediction of fetal failure was 0.831.Conclusion Progesterone,placental growth hormone and glycosylated antigen 125 at 12 and 28 weeks of gestation all had good predictive value for the pregnancy outcome of elderly patients with threatened abortion.

关 键 词：孕酮 胎盘生长激素 糖链抗原125 高龄 先兆流产 妊娠结局 

分 类 号：R714.21[医药卫生—妇产科学]