四君子汤合痛泻要方加减治疗溃疡性结肠炎(脾虚肝郁)临床观察  

Therapeutic Effect of Sijunzi Decoction and Tongxie Yaofang on the Treatment of Ulcerative Colitis with Liver Stagnation and Spleen Deficiency Syndrome

作　　者：江山[1] JIANG Shan(Changshu No.1 People's Hospital,Changshu 215500,Jiangsu,China)

机构地区：[1]常熟市第一人民医院中医科,江苏常熟215500

出　　处：《实用中医内科杂志》2020年第3期83-86,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：江苏省青年自然科学基金(BK20140293)。

摘　　要：目的探索四君子汤合痛泻要方加减治疗溃疡性结肠炎(脾虚肝郁)的疗效。方法选取2014年3月21日-2018年3月21日40例溃疡性结肠炎(脾虚肝郁)患者为研究对象,随机分为两组,各20例,分别进行柳氮磺胺吡啶片治疗、四君子汤合痛泻要方加减治疗,随后对比两组NO(血清一氧化氮)水平、SOD(血清超氧化物歧化酶)水平、中医证候积分、总有效率、TNF-α(血清肿瘤坏死因子)、IL-6(白细胞介素-6)、IL-8(白细胞介素-8)、D-D(D二聚体)、Fib(血浆纤维蛋白原)、APTT(活化部分凝血活酶时间)、PT(凝血酶原时间)、不良反应发生率。结果观察组NO水平(65.22±5.61)μmol/L、SOD水平(428.48±19.38) U/mL、D-D(234.86±15.85)μg/L、Fib(3.18±0.53) g/L、APTT(28.31±5.42) s、PT(11.13±1.87) s、TNF-α(125.86±16.37) ng/mL、IL-6(105.13±14.54) ng/mL、IL-8(95.66±5.27) ng/mL优于对照组(P<0.05),总有效率(95.00%,19/20)高于对照组(P<0.05),治疗后15 d中医证候积分(8.79±1.44)分、治疗后30 d中医证候积分(5.34±1.71)、不良反应发生率(5.00%,1/20)低于对照组(P<0.05)。结论对溃疡性结肠炎脾虚肝郁证患者实施四君子汤合痛泻要方加减治疗效果显著,能够改善当前凝血指标和炎症因子水平,减轻当前症状积分,降低不良反应,提高总有效率。Objective: To explore the curative effect of Sijunzi Decoction and Tongxie Yaofang on the treatment of ulcerative colitis with spleen deficiency and liver stagnation syndrome.Methods: Forty patients with ulcerative colitis and spleen-deficiency and liver-stagnation syndrome were randomly divided into two groups: 20 patients were treated with sulfasalazine tablets,and Sijunzi Tang combined with diarrhea and remedies.Group NO (serum nitric oxide) levels,SOD (serum superoxide dismutase) levels,TCM syndrome scores,total effective rate,TNF-α (serum tumor necrosis factor),IL-6 (interleukin-6),IL-8 (interleukin-8),DD (D dimer),Fib (plasma fibrinogen),APTT (activated partial thromboplastin time),PT (prothrombin time),incidence of adverse reactions This experiment was selected from March 21,2014 to March 21,2018.Results: NO level (65.22 ± 5.61) μmol/L,SOD level (428.48 ± 19.38) U/mL,DD (234.86 ± 15.85) μg/L,Fib (3.18 ± 0.53) g/L,APTT (28.31 ±) 5.42) s,PT (11.13 ± 1.87) s,TNF-α (125.86 ± 16.37) ng/mL,IL-6 (105.13 ± 14.54) ng/mL,IL-8 (95.66 ±5.27) ng/mL is better than control The group (P<0.05),the total effective rate (95.00%,19/20) was higher than the control group (P<0.05),the TCM syndrome score (8.79 ± 1.44) points 15 days after treatment,and the TCM syndrome score 30 days after treatment (5.34 ± 1.71),the incidence of adverse reactions (5.00%,1/20) was lower than the control group (P<0.05).Conclusion: For patients with ulcerative colitis and spleen deficiency and liver stagnation syndrome,the treatment of Sijunzi decoction and Tongxie is effective,which can improve the current coagulation index,reduce the current symptom score,reduce adverse reactions and improve the total effective rate.

关 键 词：四君子汤合痛泻要方 溃疡性结肠炎 脾虚肝郁 NO(血清一氧化氮)水平 SOD(血清超氧化物歧化酶)水平 TNF-α(血清肿瘤坏死因子) IL-6(白细胞介素-6) IL-8(白细胞介素-8) D-D(D二聚体) Fib(血浆纤维蛋白原) APTT(活化部分凝血活酶时间) PT(凝血酶原时间) 

分 类 号：R256.34[医药卫生—中医内科学]