靛玉红与二棕榈酰磷脂酰胆碱脂质体相互作用的研究  

Interaction between indirubin and DPPC liposomes

作　　者：余丹丹 何玉珏 邬瑞光[1] YU Dan-dan;HE Yu-jue;WU Rui-guang(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488)

机构地区：[1]北京中医药大学中药学院,北京102488

出　　处：《中南药学》2020年第4期553-557,共5页Central South Pharmacy

基　　金：国家自然科学基金面上项目资助(No.81773916)。

摘　　要：目的研究靛玉红与二棕榈酰磷脂酰胆碱(DPPC)脂质体作用的特点。方法选用DPPC为膜材,采用薄膜分散法制备不同摩尔百分比的靛玉红/DPPC脂质体,采用差示扫描量热(DSC)和傅立叶变换红外光谱(FTIR)技术分析靛玉红与DPPC脂质体的相互作用。结果靛玉红分子的加入会引起DPPC脂质体热致相变行为的变化,这种变化与加入靛玉红的摩尔百分浓度有关,靛玉红分子的加入会消除DPPC脂质体的预相变,改变其主相变温度及主相变焓值。结论靛玉红可改变脂质体膜流动性并且在脂质体中的包封位置具有浓度依赖性。Objective To determine the interaction between indirubin and DPPC liposomes.Methods Indirubin liposomes with different molar percentages were prepared by thin film dispersion with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine(DPPC)as the membrane material.The interaction between indirubin and DPPC liposomes was analyzed by differential scanning calorimetry(DSC)and Fourier transform infrared spectroscopy(FTIR).Results The thermal transformation behaviors of DPPC liposomes were changed by the addition of indirubin,which was related to the molar percentage concentration of indirubin.Conclusion Indirubin can change the fluidity of liposome membrane.The position of encapsulation in the liposomes is concentration-dependent.

关 键 词：靛玉红 二棕榈酰磷脂酰胆碱 脂质体 傅立叶变换红外光谱 差示扫描量热 

分 类 号：R94[医药卫生—药剂学]