藏成药萨热十三味鹏鸟丸的质量控制  

Quality Control for Tibetan Medicine Sare Shisanwei Pengniao Pills

作　　者：魏文芝 海平 卢永昌 WEI Wenzhi;HAI Ping;LU Yongchang(Qinghai Provincial Drug Inspection and Testing Institute/Qinghai Provincial Key Laboratory of Traditional Chinese and Tibetan Medicine Modernization Research,Xining 810016,China;College of Pharmacy,Qinghai University for Nationalities)

机构地区：[1]青海省药品检验检测院/青海省中藏药现代化研究重点实验室,青海西宁810016 [2]青海民族大学药学院

出　　处：《西部中医药》2020年第2期26-29,共4页Western Journal of Traditional Chinese Medicine

基　　金：青海省药品检验检测平台项目;青海省科技厅科研基础条件平台项目(2017-ZJ-Y40);青海省科学技术成果(9632015Y0281)。

摘　　要：目的:建立藏成药萨热十三味鹏鸟丸的质量控制方法。方法:采用显微鉴别法对丁香进行鉴别,采用化学鉴别法对磁石进行鉴别;采用高效液相色谱法测定成药中去氢二异丁香酚含量。结果:丁香、磁石的鉴别方法斑点清晰,反应灵敏,阴性无干扰,具有较好的专属性;去氢二异丁香酚在0.04183~209.1 mg/L范围内线性关系良好(r=0.9996),平均回收率为101.27%,RSD为1.35%;结论:所建立的方法定性定量准确,重现性好,可有效控制该藏成药的制剂质量。Objective:To establish the method for quality control of Tibetan medicine Sare Shisanwei Pengniao pills.Methods:Microscopic identification was used to distinguish Dingxiang(caryophylli flos),chemical identification to distinguish Cishi(magnetitum),HPLC to measure the contents of dehydrodiisobuterol contained in Tibetan medicine.Results:The identification methods of Dingxiang and Cishi were distinct,sensitive,negative and specific,and the blank test showed no interference;dehydrodiisobuterol presented good linear relationship in the range from0.04183 to 209.1 mg/L,average recovery rate was 101.27%,RSD was 1.35%.Conclusion:The method,qualitative,quantitative,accurate and reproducible,could effectively control the quality of Tibetan medicine.

关 键 词：萨热十三味鹏鸟丸 显微鉴别 化学鉴别 高效液色相谱法 含量测定 去氢二异丁香酚 丁香 磁石 藏药 

分 类 号：R285[医药卫生—中药学]