基于生物信息学探讨骨质疏松症与2型糖尿病的关系  

Investigating the relationship between osteoporosis and type 2 diabetes mellitus based on bioinformatics

作　　者：冯蓬 陈德强[1] FENG Peng;CHEN Deqiang(Shandong University of Traditional Chinese Medicine,Ji'nan 250355,China)

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《中国骨质疏松杂志》2020年第4期469-473,共5页Chinese Journal of Osteoporosis

摘　　要：目的基于生物信息学探讨骨质疏松症与2型糖尿病的关系。方法通过五大疾病数据库(Disgenet、TTD、OMIM、Drugbank、KEGG数据库)和分析平台(DAVID数据库)对骨质疏松症和2型糖尿病的相关基因进行分析筛选,并对筛选结果进行基因富集分析以及KEGG通路分析。结果通过五大疾病数据库及相关文献筛选分别选出与骨质疏松症和2型糖尿病相关基因336个和316个,并将数据导入DAVID数据库进行基因富集分析以及KEGG通路分析,结果骨质疏松症与2型糖尿病相关通路集中在PI3K-Akt信号通路、FoxO信号通路、HIF-1信号通路、AMPK信号通路、Rap1信号通路、Jak-STAT信号通路、Ras信号通路、NF-kappa B信号通路、T细胞信号通路、TNF信号通路、VEGF信号通路、脂肪细胞因子信号通路、fc-εri信号通路。结论骨质疏松症与2型糖尿病均是涵盖众多差异表达基因的复杂代谢性疾病,两种疾病均存在庞大的基因表达网络,涉及众多信号通路。从通路分析结果中可以看出,两种疾病复杂基因网络背景下依然存在一些高度重合的差异基因表达,所涉及的信号通路能够同时对两种疾病产生调控作用,这提示两种疾病分子机制存在密切关联,并可能是药物同时干预两种疾病的靶点所在。Objective To investigate the relationship between osteoporosis and type 2 diabetes mellitus based on bioinformatics.Methods Five major disease databases(Disgenet,TTD,OMIM,Drugbank,and KEGG database)and analysis platform(DAVID database)were used to analyze and screen related genes of osteoporosis and type 2 diabetes.Results 336 and 316 genes related to osteoporosis and type 2 diabetes,respectively,were selected by screening the five major disease databases and related literatures.The data were imported into DAVID database for gene enrichment analysis and KEGG pathway analysis.Analysis result showed that osteoporosis and type 2 diabetes related pathways include PI3K-Akt signaling pathways,FoxO signal pathway,HIF-1 signaling pathways,AMPK pathway,HIF-1 Rap1 signaling pathways,Jak-STAT signal pathway,Ras signaling pathways,NF kappa B signaling pathways,T cell signaling pathways,TNF signaling pathways,VEGF signaling pathways,fat cytokine signaling pathways and fc-epsilon ri signaling pathways.Conclusion Both osteoporosis and type 2 diabetes are complex metabolic diseases that involve many differentially expressed genes.Both diseases have large gene expression networks involving many signaling pathways.It can be seen from the pathway analysis result that there are still some highly overlapping differential gene expression under the background of the complex gene network of the two diseases.The signaling pathways involved can regulate both diseases at the same time,which indicates that the molecular mechanisms of the two diseases are closely related and may be the target of drug intervention in both diseases.

关 键 词：生物信息学 骨质疏松症 2型糖尿病 分子机制 疾病相互关系 

分 类 号：R681[医药卫生—骨科学] R587.1[医药卫生—外科学]