姜黄素PLGA纳米颗粒的制备及表征  

Preparation and Characterization of Curcumin PLGA Nanoparticles

作　　者：朱迪冰 赵海燕[1] 何建丹 杜雨涵 王少兵[1] Zhu Dibing;Zhao Haiyan;He Jiandan;Du Yuhan;Wang Shaobing(School of Pharmaceutical Sciences,South-Central University for Nationalities,Wuhan 430074,China)

机构地区：[1]中南民族大学药学院,湖北武汉430074

出　　处：《亚太传统医药》2020年第3期46-49,共4页Asia-Pacific Traditional Medicine

基　　金：国家自然科学基金(81703464)。

摘　　要：目的:筛选姜黄素PLGA纳米粒(Cur-PLGA-NPs)制备的最优处方,并对制备的纳米粒进行表征。方法:以聚乳酸羟基乙酸共聚物(PLGA)为载体材料,采用乳化溶剂挥发法制备Cur-PLGA-NPs,通过单因素试验,以粒径、包封率和载药量为指标,筛选了Cur-PLGA-NPs的最优处方,并以红外光谱(IR)、差示扫描量热法(DSC)、X射线衍射(XRD)以及透射电子显微镜(TEM)等手段进行了表征。结果:按优化条件制备的Cur-PLGA-NPs包封率为(49.1±1.68)%,载药量为(4.5±0.15)%,平均粒径为(167.5±4.3)nm,药物和辅料间不存在相互作用力。结论:采用乳化溶剂挥发法成功制备了Cur-PLGA-NPs,为Cur-PLGA-NPs的体内研究奠定了基础。Objective:To prepare curcumin PLGA nanoparticles(Cur-PLGA-NPs),the optimal formulation was screened and characterized.Methods:Cur-PLGA-NPs were prepared by the emulsion solvent evaporation technique with PLGA as the carrier,and the optimal formulation of Cur-PLGA-NPs was screened by single factor test with particle size,encapsulation efficiency and drug loading as the index,and the IR,DSC,XRD and TEM were used to characterize.Results:The mean particle size of the resulted Cur-PLGANPs was(167.5 4.3)nm and the average entrapment efficiency and drug-loading was(49.1 1.68)% and(4.5 0.15)%,respectively.And there is no interaction between the drug and the auxiliary materials.Conclusion:Cur-PLGA-NPs was successfully prepared by emulsion solvent evaporation method,which laid a foundation for the in vivo study of Cur-PLGA-NPs.

关 键 词：姜黄素 PLGA纳米粒 乳化溶剂挥发法 

分 类 号：R283[医药卫生—中药学]